Trial reportBalkan medical journal2021
Comparison of BPAP S/T and Average Volume-Assured Pressure Support Modes for Hypercapnic Respiratory Failure in the Emergency Department: A Randomized Controlled Trial.
Trial report in Balkan medical journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06047405 (NIV for Hypercapnic Respiratory Failure), which is not on this map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
NIV for Hypercapnic Respiratory Failure: AVAPS vs S/T BIPAP
Who cites it
4 citing papers in PubMed, 10 citations in OpenAlex.
- Beyond blood gases: diaphragm-guided sequential non-invasive ventilation for COPD with type II respiratory failure.Frontiers in medicine · 2026Review
- The key to AVAPS success: Emphasizing proper patient selection following fixedlevel PS-NIV use in respiratory failure.Tuberkuloz ve toraks · 2023Article
- Comment on "Average Volume-Assured Pressure Support Modes for Hypercapnic Respiratory Failure: Its Early Use in the Emergency Department".Balkan medical journal · 2022Article
- In Response to "Comment on Average Volume-Assured Pressure Support Modes for Hypercapnic Respiratory Failure its early use in the Emergency Department".Balkan medical journal · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is limited research into the utility of average volume- assured pressure support (AVAPS), a volume-assured pressure-controlled mode, especially in patients with hypercapnic respiratory failure.
aimsThis study aimed at a randomized comparison of AVAPS and bilevel positive airway pressure spontaneous/timed (BPAP S/T) modes in non-invasive mechanical ventilation application with hypercapnic respiratory failure patients in the emergency department. STUDY
designRandomized controlled study.
methodsEighty of 140 patients admitted to the emergency department with hypercapnic respiratory failure requiring non-invasive mechanical ventilation were randomly assigned to the AVAPS or S/T groups (33 patients in the S/T group, 47 patients in the AVAPS group) using the sealed envelope method. Data of arterial blood gas, vital parameters, Glasgow Coma Score, additional treatment needs, and clinical outcomes were evaluated, and the treatment success rates of both groups were compared.
resultsA total of 80 patients, 33 in the S/T and 47 in the AVAPS group, were analyzed in the study. The pH values improved in the AVAPS group compared to the baseline (0.07 [0.04-0.10] vs 0.03 [0.00-0.11]). PaCO2 (partial pressure of carbon dioxide) excretion was faster in the AVAPS group than in the S/T group in the first hour (10.20 mmHg [6.20-19.20] vs. 4.75 ([-] 0.83-16.88)). The comparison of blood gas measurements showed no significant differences between the groups regarding the changes in PaCO2 and pH values over time (P = .141 and P = .271, respectively). During the emergency department follow-up, 3 (6.4%) patients in the AVAPS group and 5 (15.2%) patients in the S/T group needed intubation [Relative risk: 0.42 (95% CI: 0.11 to 1.64), P = .21].
conclusionThe AVAPS mode is as effective and safe as BPAP S/T in treating patients with hypercapnic respiratory failure in the emergency department.
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