Evidence map›Paper›PMID 34462187›Full record

ArticleTrends in microbiology2021

Rapid Proliferation Compensates for Defective Filamentation in Candida albicans Pathogenesis.

David Kadosh

Abstract readComment
In one paragraph

Article in Trends in microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

David KadoshDepartment of Microbiology, Immunology, and Molecular Genetics, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr., MC: 7758, San Antonio, Texas 78229, USA. Electronic address: kadosh@uthscsa.edu.

Funding

Translational Control of Morphology and Virulence in Candida albicansR01AI127692 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI KADOSH, DAVID · 2018 to 2022
$1.9M
Regulation of Protein Synthesis During the C. albicans-Macrophage InteractionR21AI142560 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI KADOSH, DAVID · 2019 to 2020
$435k
Regulation of Multidrug Resistance in the Emerging Human Fungal Pathogen Candida aurisR21AI164719 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI KADOSH, DAVID · 2021 to 2022
$426k
NIAID NIH HHS R01 AI127692NIAID NIH HHS R21 AI142560NIAID NIH HHS R21 AI164719
6 · The paper itself

Abstract

A recent study (Dunker et al.) has shown that a Candida albicans mutant, defective for filamentation, is fully virulent due to rapid cellular proliferation in host tissues. These findings challenge the current paradigm in C. albicans pathogenesis and suggest that defects in one virulence property can be compensated for by enhancements in another.

Indexed as

Candida albicansHyphaeCell ProliferationVirulenceCandida albicanscellular proliferationfilamentsmetabolic adaptationmorphologypathogenesisyeast

Identifiers

PMID34462187
PMCPMC8815434

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.