Evidence map›Paper›PMID 34461993›Full record

ArticleStem cell research & therapy2021

Intratracheal transplantation of trophoblast stem cells attenuates acute lung injury in mice.

Junwen Han, Gu Li, Minmin Hou, Julie Ng, Min-Young Kwon, Kevin Xiong, Xiaoliang Liang, Elizabeth Taglauer, Yuanyuan Shi, S Alex Mitsialis and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell research & therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 2 countries.

Junwen HanDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA.
Gu LiDepartment of Surgery, Brigham and Women's Hospital, Boston, MA, 02115, USA.
Minmin HouDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA.
Julie NgDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA.
Min-Young KwonDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA.
Kevin XiongDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA.
Xiaoliang LiangDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA.
Elizabeth TaglauerDepartment of Pediatrics, Division of Newborn Medicine, Boston Children's Hospital, Boston, MA, 02115, USA.
Yuanyuan ShiSchool of Life Sciences, Beijing University of Chinese Medicine, Beijing, 100029, China.
S Alex MitsialisDepartment of Pediatrics, Division of Newborn Medicine, Boston Children's Hospital, Boston, MA, 02115, USA.
Stella KourembanasDepartment of Pediatrics, Division of Newborn Medicine, Boston Children's Hospital, Boston, MA, 02115, USA.
Souheil El-ChemalyDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA.
James A LedererDepartment of Surgery, Brigham and Women's Hospital, Boston, MA, 02115, USA.
Ivan O RosasDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA.
Mark A PerrellaDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA.
Xiaoli LiuDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA. xlliu@rics.bwh.harvard.edu.ORCID 0000-0003-2904-4413
Brigham and Women's Hospital · USBoston Children's Hospital · USBeijing University of Chinese Medicine · CN

Funding

Therapy of acute radiation syndrome and its complications by mesenchymal stromal cells conditioned with Toll-like receptor 9 agonistsU01AI138318 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI LEDERER, JAMES A., PERRELLA, MARK A · 2018 to 2022
$3.1M
Lymphatics and Lung Allograft RejectionR01HL130275 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI EL-CHEMALY, SOUHEIL · 2016 to 2020
$2.2M
Mesenchymal Stromal Cells, Autophagy, and the Host Response to Systemic Bacterial InfectionR01GM136804 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI PERRELLA, MARK A · 2020 to 2023
$1.4M
NHLBI NIH HHS R01 HL130275NIAID NIH HHS U01 AI138318NIGMS NIH HHS R01 GM136804NIH HHS U01AI38318
6 · The paper itself

Abstract

backgroundAcute lung injury (ALI) is a common lung disorder that affects millions of people every year. The infiltration of inflammatory cells into the lungs and death of the alveolar epithelial cells are key factors to trigger a pathological cascade. Trophoblast stem cells (TSCs) are immune privileged, and demonstrate the capability of self-renewal and multipotency with differentiation into three germ layers. We hypothesized that intratracheal transplantation of TSCs may alleviate ALI.

methodsALI was induced by intratracheal delivery of bleomycin (BLM) in mice. After exposure to BLM, pre-labeled TSCs or fibroblasts (FBs) were intratracheally administered into the lungs. Analyses of the lungs were performed for inflammatory infiltrates, cell apoptosis, and engraftment of TSCs. Pro-inflammatory cytokines/chemokines of lung tissue and in bronchoalveolar lavage fluid (BALF) were also assessed.

resultsThe lungs displayed a reduction in cellularity, with decreased CD45

conclusionIntratracheal transplantation of TSCs into the lungs of mice after acute exposure to BLM reduced pulmonary inflammation and cell death. Furthermore, TSCs engrafted into the alveolar walls to form alveolar epithelial type I and II cells. These data support the use of TSCs for the treatment of ALI.

Indexed as

Acute Lung InjuryTrophoblastsAlveolar Epithelial CellsAnimalsBronchoalveolar Lavage FluidLipopolysaccharidesLungMiceMice, Inbred C57BLStem CellsLipopolysaccharidesAcute lung injuryAlveolar epithelial cellsEngraftmentInflammationTrophoblast stem cells

Identifiers

PMID34461993
PMCPMC8404310
OpenAlexW3197245521

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.