ReviewGenetics, selection, evolution : GSE2021
Evidence for and localization of proposed causative variants in cattle and pig genomes.
Review in Genetics, selection, evolution : GSE, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Comparison of two multi-trait association testing methods and sequence-based fine mapping of six additive QTL in Swiss Large White pigs.BMC genomics · 2023Pooled it
- Resolving Cattle GWAS Loci: Current Progress, Persistent Challenges and Future Directions.Current issues in molecular biology · 2026Review
- Causal variants in animal genomes: approaches to identification, phenotypic impact, and implications for selective breeding.BMC genomics · 2026Review
- Identification and bioinformatic functional analysis of novel and known polymorphisms in the myostatin gene of Ukrainian Carpathian Mountain sheep.Scientific reports · 2026Article
- Assessing the effect of bovine MSTN variants on pre-mRNA splicing.Animal genetics · 2026Article
- Functional Mutations in theVeterinary sciences · 2025Article
- Sequence-based GWAS in 180,000 German Holstein cattle reveals new candidate variants for milk production traits.Genetics, selection, evolution : GSE · 2025Article
- Bioinformatic approach to identifying causative missense polymorphisms in animal genomes.BMC genomics · 2024Article
- Article
- A DIO2 missense mutation and its impact on fetal response to PRRSV infection.BMC veterinary research · 2024Article
- Identification and characterization of whole blood gene expression and splicing quantitative trait loci during early to mid-lactation of dairy cattle.BMC genomics · 2024Article
- Article
- A genome-wide association study for loin depth and muscle pH in pigs from intensely selected purebred lines.Genetics, selection, evolution : GSE · 2023Article
- Review
- CLARITY: a Shiny app for interactive visualisation of the bovine physical-genetic map.Frontiers in genetics · 2023Article
- Identification of a missense variant in the porcine AGPAT gene family associated with intramuscular fat content through whole-genome sequencing.Animal genetics · 2022Article
- Genomic prediction with whole-genome sequence data in intensely selected pig lines.Genetics, selection, evolution : GSE · 2022Article
- Enhancer-promoter interaction maps provide insights into skeletal muscle-related traits in pig genome.BMC biology · 2022Article
- Comparison of the choice of animals for re-sequencing in two maternal pig lines.Genetics, selection, evolution : GSE · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundThis paper reviews the localization of published potential causative variants in contemporary pig and cattle reference genomes, and the evidence for their causality. In spite of the difficulties inherent to the identification of causative variants from genetic mapping and genome-wide association studies, researchers in animal genetics have proposed putative causative variants for several traits relevant to livestock breeding.
resultsFor this review, we read the literature that supports potential causative variants in 13 genes (ABCG2, DGAT1, GHR, IGF2, MC4R, MSTN, NR6A1, PHGK1, PRKAG3, PLRL, RYR1, SYNGR2 and VRTN) in cattle and pigs, and localized them in contemporary reference genomes. We review the evidence for their causality, by aiming to separate the evidence for the locus, the proposed causative gene and the proposed causative variant, and report the bioinformatic searches and tactics needed to localize the sequence variants in the cattle or pig genome.
conclusionsTaken together, there is usually good evidence for the association at the locus level, some evidence for a specific causative gene at eight of the loci, and some experimental evidence for a specific causative variant at six of the loci. We recommend that researchers who report new potential causative variants use referenced coordinate systems, show local sequence context, and submit variants to repositories.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.