Evidence map›Paper›PMID 34461606›Full record

ArticleAging2021

Immune normalization strategy against suboptimal health status: safe and efficacious therapy using mixed-natural killer cells.

Ying Li, Oda Harunori, Shihu Fu, Fuyuan Xing, Huawan Wu, Juan Wang, Aihua Chen, Xinhua Ren, Dawei Peng, Xia Ling and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 59% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Ying LiInternational Research Center for Regenerative Medicine, BOAO International Hospital, Qionghai 571434, Hainan, China.
Oda HarunoriInternational Research Center for Regenerative Medicine, BOAO International Hospital, Qionghai 571434, Hainan, China.
Shihu FuInternational Research Center for Regenerative Medicine, BOAO International Hospital, Qionghai 571434, Hainan, China.
Fuyuan XingInternational Research Center for Regenerative Medicine, BOAO International Hospital, Qionghai 571434, Hainan, China.
Huawan WuInternational Research Center for Regenerative Medicine, BOAO International Hospital, Qionghai 571434, Hainan, China.
Juan WangInternational Research Center for Regenerative Medicine, BOAO International Hospital, Qionghai 571434, Hainan, China.
Aihua ChenInternational Research Center for Regenerative Medicine, BOAO International Hospital, Qionghai 571434, Hainan, China.
Xinhua RenInternational Research Center for Regenerative Medicine, BOAO International Hospital, Qionghai 571434, Hainan, China.
Dawei PengInternational Research Center for Regenerative Medicine, BOAO International Hospital, Qionghai 571434, Hainan, China.
Xia LingInternational Research Center for Regenerative Medicine, BOAO International Hospital, Qionghai 571434, Hainan, China.
Ming ShiSchool of Life Science and Technology, Harbin Institute of Technology, Harbin 150001, Heilongjiang, China.
Hongjin WuInternational Research Center for Regenerative Medicine, BOAO International Hospital, Qionghai 571434, Hainan, China.
Harbin Institute of Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

"Immune normalization" has emerged as a new paradigm in immunotherapy, which is proposed in cancer patients instead of conventional "immune-enhancement" therapy. Immune normalization may also be implemented in cancer prevention of "sub-healthy" individuals. We established

Indexed as

AntigensHealth StatusAdjuvants, ImmunologicAgedCD3 ComplexCD56 AntigenCD8-Positive T-LymphocytesCell Culture TechniquesHumansImmune SystemImmunityImmunotherapyKiller Cells, NaturalLeukocytes, MononuclearLymphomaMiddle AgedAdjuvants, ImmunologicAntigensCD3 ComplexCD56 AntigenProgrammed Cell Death 1 ReceptorReceptors, IgGCD16CD56immune cell therapynatural killer cellsPD-1

Identifiers

PMID34461606
PMCPMC8436936
OpenAlexW3197563696

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.