Evidence map›Paper›PMID 34461584›Full record

Trial reportClinical nutrition (Edinburgh, Scotland)2021

Longitudinal assessments of child growth: A six-year follow-up of a cluster-randomized maternal education trial.

Prudence Atukunda, Moses Ngari, Xi Chen, Ane C Westerberg, Per O Iversen, Grace Muhoozi

Registry-linked trialAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Clinical nutrition (Edinburgh, Scotland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02098031 (Improving the Nutrition Status of 6 to 8 Months Old Children Through Diet Diversification and Better Dietary Intakes in the Kabale and Kisoro Districts in South-Western Uganda), which is not on this map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02098031 nacompletednot on this map

Improving the Nutrition Status of 6 to 8 Months Old Children Through Diet Diversification and Better Dietary Intakes in the Kabale and Kisoro Districts in South-Western Uganda

TypeinterventionalSponsorUniversity of OsloRan2014 to 2016Enrolled511ConditionsInfant Malnutrition, Nutrition Knowledge, Growth, Cognitive DevelopmentArmsImproving nutrition knowledge among mothers
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Prudence AtukundaDepartment of Nutrition, University of Oslo, Norway. Electronic address: prudence.atukunda@studmed.uio.no.
Moses NgariThe Childhood Acute Illness & Nutrition Network (CHAIN), Nairobi, Kenya; KEMRI/Wellcome Trust Research Programme, Kilifi, Kenya. Electronic address: MNgari@kemri-wellcome.org.
Xi ChenDepartment of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China. Electronic address: chenxi2917@163.com.
Ane C WesterbergInstitute of Health Sciences, Kristiania University College, Oslo, Norway; Division of Obstetrics and Gynecology, Oslo University Hospital, Oslo, Norway. Electronic address: anewes@ous-hf.no.
Per O IversenDepartment of Nutrition, University of Oslo, Norway; Department of Haematology, Oslo University Hospital, Oslo, Norway; Division of Human Nutrition, Stellenbosch University, Tygerberg, South Africa. Electronic address: p.o.iversen@medisin.uio.no.
Grace MuhooziDepartment of Human Nutrition and Home Economics, Kyambogo University, Kampala, Uganda. Electronic address: g.k.m.muhoozi@medisin.uio.no.

Funding

Wellcome Trust 203077
6 · The paper itself

Abstract

BACKGROUND &

aimsChild growth impairments are rampant in sub-Saharan Africa. To combat this important health problem, long-term follow-up studies are needed to examine possible benefits and sustainability of various interventions designed to correct inadequate child growth. Our aim was to perform a follow-up study of children aged 60-72 months whose mothers participated in a two-armed cluster-randomized education intervention trial lasting 6 months in rural Uganda when their children were 6-8 months old with data collection at 20-24 and at 36 months. The education focused on nutrition, hygiene, and child stimulation.

methodsWe measured growth using anthropometry converted to z-scores according to WHO guidelines. We also included assessments of body composition using bioimpedance. We used multilevel mixed effect linear regression models with maximum likelihood method, unstructured variance-covariance structure, and the cluster as a random effect component to compare data from the intervention (receiving the education and routine health care) with the control group (receiving only routine health care).

resultsOf the 511 children included in the original trial, data from 166/263 (63%) and 141/248 (57%) of the children in the intervention and control group, respectively, were available for the current follow-up study. We found no significant differences in any anthropometrical z-score between the two study groups at child age of 60-72 months, except that children in the intervention group had lower (P = 0.006) weight-for-height z-score than the controls. There were no significant differences in the trajectories of z-scores or height growth velocity (cm/year) from baseline (start of original trial) to child age of 60-72 months. Neither did we detect any significant difference between the intervention and control group regarding body composition (fat mass, fat free mass, and total body water) at child age 60-72 months. Separate gender analyses had no significant impact on any of the growth or body composition findings.

conclusionIn this long-term study of children participating in a randomized maternal education trial, we found no significant impact of the intervention on anthropometrical z-scores, height growth velocity or body composition.

trial registrationClinical Trials (clinical trials.gov) ClinicalTrials.gov ID NCT02098031.

Indexed as

Body-Weight TrajectoryChild DevelopmentAnthropometryBody CompositionChildChild, PreschoolCluster AnalysisEducation, NonprofessionalElectric ImpedanceFemaleFollow-Up StudiesHealth EducationHumansInfantLinear ModelsLongitudinal StudiesBody compositionGrowth impairmentGrowth velocityMaternal educationStuntingSub-Saharan Africa

Identifiers

PMID34461584
PMCPMC7613314

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.