Evidence map›Paper›PMID 34461436›Full record

ArticleNeuroImage. Clinical2021

Premotor and fronto-striatal mechanisms associated with presence hallucinations in dementia with Lewy bodies.

Nicolas Nicastro, Giedre Stripeikyte, Frédéric Assal, Valentina Garibotto, Olaf Blanke

Open access · goldAbstract read
In one paragraph

Article in NeuroImage. Clinical, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Nicolas NicastroDivision of Neurology, Department of Clinical Neurosciences, Geneva University Hospitals, Geneva, Switzerland; Faculty of Medicine, University of Geneva, Switzerland. Electronic address: nicolas.nicastro@hcuge.ch.
Giedre StripeikyteCenter for Neuroprosthetics, Swiss Federal Institute of Technology (EPFL), Geneva, Switzerland; Brain Mind Institute, Faculty of Life Sciences, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.
Frédéric AssalDivision of Neurology, Department of Clinical Neurosciences, Geneva University Hospitals, Geneva, Switzerland; Faculty of Medicine, University of Geneva, Switzerland.
Valentina GaribottoFaculty of Medicine, University of Geneva, Switzerland; Division of Nuclear Medicine, Geneva University Hospitals, Geneva, Switzerland.
Olaf BlankeDivision of Neurology, Department of Clinical Neurosciences, Geneva University Hospitals, Geneva, Switzerland; Center for Neuroprosthetics, Swiss Federal Institute of Technology (EPFL), Geneva, Switzerland; Brain Mind Institute, Faculty of Life Sciences, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.
École Polytechnique Fédérale de Lausanne · CHUniversity Hospital of Geneva · CHGeneva College · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionpresence hallucinations (PH) are frequent in dementia with Lewy bodies (DLB), but their cortico-subcortical origin is unknown. Recent studies have defined key frontal and temporal areas contributing to the occurrence of PH (PH-network) and tested their relevance in subjects with Parkinson's disease (PD). With the present study, we aimed at disentangling the metabolic and dopaminergic correlates of pH as well as their relation to a recently defined PH brain network in DLB.

methodsfor the present study, we included 34 DLB subjects (10 with PH (PH + ); 24 without PH (PH-)), who underwent

resultsPH + versus PH- had reduced DISCUSSION: these findings uncover the pivotal role of vPMC (involved in a PH-network) and its cortico-striatal connections in association with PH in DLB, improving our understanding of psychosis in neurodegeneration.

Indexed as

Lewy Body DiseaseParkinson DiseaseCorpus StriatumHallucinationsHumansTomography, Emission-Computed, Single-PhotonBrain metabolismDementiaDopamineHallucinationsPsychosis

Identifiers

PMID34461436
PMCPMC8403753
OpenAlexW3197332324

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.