ArticleThe Journal of hospital infection2021
Explosive nosocomial outbreak of SARS-CoV-2 in a rehabilitation clinic: the limits of genomics for outbreak reconstruction.
Article in The Journal of hospital infection, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- A statistical framework for comparing epidemic forests.PLoS computational biology · 2026Article
- Minimising the duration of N95 respirator use during hospital SARS-CoV-2 outbreaks: A mixed-effects analysis of post-screening infection reduction.Infection prevention in practice · 2025Article
- Article
- Genomic Epidemiology of Severe Acute Respiratory Syndrome Coronavirus 2 in a County Jail.Open forum infectious diseases · 2024Article
- Proposed new definition for hospital-acquired SARS-CoV-2 infections: results of a confirmatory factor analysis.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2024Article
- Sorting out assortativity: When can we assess the contributions of different population groups to epidemic transmission?PloS one · 2024Article
- Coronavirus disease 2019 (COVID-19) outbreak on an in-patient medical unit associated with unrecognized exposures in common areas-Epidemiological and whole-genome sequencing investigation.Infection control and hospital epidemiology · 2023Article
- SARS-CoV-2 Outbreak Investigation Using Contact Tracing and Whole-Genome Sequencing in an Ontario Tertiary Care Hospital.Microbiology spectrum · 2023Article
- Combining epidemiological data and whole genome sequencing to understand SARS-CoV-2 transmission dynamics in a large tertiary care hospital during the first COVID-19 wave in The Netherlands focusing on healthcare workers.Antimicrobial resistance and infection control · 2023Article
- Impact of supplementary air filtration on aerosols and particulate matter in a UK hospital ward: a case study.The Journal of hospital infection · 2023Article
- Patient and ward related risk factors in a multi-ward nosocomial outbreak of COVID-19: Outbreak investigation and matched case-control study.Antimicrobial resistance and infection control · 2023Article
- Lessons learned: use of WGS in real-time investigation of suspected intrahospital SARS-CoV-2 outbreaks.The Journal of hospital infection · 2023Article
- Genomic Investigation to Identify Sources of Severe Acute Respiratory Syndrome Coronavirus 2 Infection Among Healthcare Personnel in an Acute Care Hospital.Open forum infectious diseases · 2022Article
- COVID-19 infection and renal injury: where is the place for acute interstitial nephritis disease?Clinical kidney journal · 2022Article
- Prediction of hospital-onset COVID-19 infections using dynamic networks of patient contact: an international retrospective cohort study.The Lancet. Digital health · 2022Article
- Repeated transmission of SARS-CoV-2 in an overcrowded Irish emergency department elucidated by whole-genome sequencing.The Journal of hospital infection · 2022Article
- Article
- Occupational and community risk of SARS-CoV-2 infection among employees of a long-term care facility: an observational study.Antimicrobial resistance and infection control · 2022Observational
- Characterising within-hospitalSARS-CoV-2 transmission events using epidemiological and viral genomic data across two pandemic waves.Nature communications · 2022Article
- Local Emergence of a del HV69-70 SARS-CoV-2 Variant in Burgundy, France.Pathogens (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
backgroundNosocomial outbreaks of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) are frequent despite implementation of conventional infection control measures. An outbreak investigation was undertaken using advanced genomic and statistical techniques to reconstruct likely transmission chains and assess the role of healthcare workers (HCWs) in SARS-CoV-2 transmission.
methodsA nosocomial SARS-CoV-2 outbreak in a university-affiliated rehabilitation clinic was investigated, involving patients and HCWs, with high coverage of pathogen whole-genome sequences (WGS). The time-varying reproduction number from epidemiological data (R
findingsThe outbreak lasted from 14
interpretationThis outbreak report highlights the essential role of HCWs in SARS-CoV-2 transmission dynamics in healthcare settings. Limited genetic diversity in pathogen genomes hampered the reconstruction of individual transmission events, resulting in substantial uncertainty in who infected whom. However, this study shows that despite such uncertainty, significant transmission patterns can be observed.
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