Evidence map›Paper›PMID 34461148›Full record

ArticlePharmacology, biochemistry, and behavior2021

Confronting the challenge of failed translation in medications development for substance use disorders.

S S Negus, M L Banks

Abstract read
In one paragraph

Article in Pharmacology, biochemistry, and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Repeated semaglutide treatment attenuates cocaine-vs-food choice in male and female rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  3. Sex-specific role of the 5-HTNature communications · 2025
    Article
  4. Review
  5. Review
  6. Human laboratory models of reward in substance use disorder.Pharmacology, biochemistry, and behavior · 2024
    Review
  7. Differential disruption of response alternation by precipitated ΔPharmacology, biochemistry, and behavior · 2024
    Article
  8. An economon model of drug addiction.Psychopharmacology · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

S S NegusDepartment of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, United States of America. Electronic address: sidney.negus@vcuhealth.org.
M L BanksDepartment of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, United States of America.

Funding

VCU Center for Drug Addiction ResearchP30DA033934 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI JOLENE J WINDLE · 2014 to 2026
$13.8M
Medications Development for Stimulant AbuseR01DA026946 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI NEGUS, SIDNEY S · 2009 to 2019
$3.7M
NIDA NIH HHS P30 DA033934NIDA NIH HHS R01 DA026946
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Analgesics, OpioidCOVID-19DextroamphetamineDopamine AgonistsDopamine AntagonistsDrug DevelopmentDrug OverdoseEthanolHumansNicotianaSARS-CoV-2Self AdministrationSubstance-Related DisordersAnalgesics, OpioidDextroamphetamineDopamine AgonistsDopamine AntagonistsEthanolAddictionMedications developmentSubstance use disorderTranslationTreatment

Identifiers

PMID34461148
PMCPMC8418188

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.