Evidence map›Paper›PMID 34461129›Full record

ArticleThe Journal of investigative dermatology2022

Epidermis-Intrinsic Transcription Factor Ovol1 Coordinately Regulates Barrier Maintenance and Neutrophil Accumulation in Psoriasis-Like Inflammation.

Morgan Dragan, Peng Sun, Zeyu Chen, Xianghui Ma, Remy Vu, Yuling Shi, S Armando Villalta, Xing Dai

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of investigative dermatology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Morgan DraganDepartment of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, California, USA; NSF-Simons Center for Multiscale Cell Fate Research, University of California, Irvine, Irvine, California, USA; Institute for Immunology, University of California, Irvine, Irvine, California, USA.
Peng SunDepartment of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, California, USA.
Zeyu ChenDepartment of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, California, USA; Department of Dermatology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China; Institute of Psoriasis, School of Medicine, Tongji University, Shanghai, China.
Xianghui MaDepartment of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, California, USA.
Remy VuDepartment of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, California, USA; NSF-Simons Center for Multiscale Cell Fate Research, University of California, Irvine, Irvine, California, USA.
Yuling ShiInstitute of Psoriasis, School of Medicine, Tongji University, Shanghai, China; Department of Dermatology, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China.
S Armando VillaltaInstitute for Immunology, University of California, Irvine, Irvine, California, USA; Department of Physiology & Biophysics, School of Medicine, University of California, Irvine, Irvine, California, USA.
Xing DaiDepartment of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, California, USA; NSF-Simons Center for Multiscale Cell Fate Research, University of California, Irvine, Irvine, California, USA; Institute for Immunology, University of California, Irvine, Irvine, California, USA. Electronic address: xdai@uci.edu.
University of California, Irvine · USTongji University · CN

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Melanie Funes · 1994 to 2026
$57.9M
Multiscale Models of Wound Cell Plasticity for RegenerationU01AR073159 · NIAMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI DAI, XING, NIE, QING · 2018 to 2022
$3.5M
Immunology Research Training ProgramT32AI060573 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI PEARLMAN, ERIC · 2005 to 2020
$1.9M
Mammary basal/stem cell plasticity and regulationR01GM123731 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI DAI, XING · 2017 to 2020
$1.9M
Control of epithelial plasticity and differentiation in hair follicle stem/progenitor cellsR01AR068074 · NIAMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI DAI, XING · 2015 to 2019
$1.7M
NCI NIH HHS P30 CA062203NIAID NIH HHS T32 AI060573NIAMS NIH HHS R01 AR068074NIAMS NIH HHS U01 AR073159NIGMS NIH HHS R01 GM123731
6 · The paper itself

Abstract

Skin epidermis constitutes the exterior barrier that protects the body from dehydration and environmental assaults. Barrier defects underlie common inflammatory skin diseases, but the molecular mechanisms that maintain barrier integrity and regulate epidermal-immune cell cross-talk in inflamed skin are not fully understood. In this study, we show that skin epithelia-specific deletion of Ovol1, which encodes a skin disease‒linked transcriptional repressor, impairs the epidermal barrier and aggravates psoriasis-like skin inflammation in mice in part by enhancing neutrophil accumulation and abscess formation. Through molecular studies, we identify IL-33, a cytokine with known pro-inflammatory and anti-inflammatory activities, and Cxcl1, a neutrophil-attracting chemokine, as potential weak and strong direct targets of Ovol1, respectively. Furthermore, we provide functional evidence that elevated Il33 expression reduces disease severity in imiquimod-treated Ovol1-deficient mice, whereas persistent accumulation and epidermal migration of neutrophils exacerbate it. Collectively, our study uncovers the importance of an epidermally expressed transcription factor that regulates both the integrity of the epidermal barrier and the behavior of neutrophils in psoriasis-like inflammation.

Indexed as

DermatitisPsoriasisAnimalsDisease Models, AnimalDNA-Binding ProteinsEpidermisInflammationIntrinsic FactorKeratinocytesMiceNeutrophilsSkinTranscription FactorsDNA-Binding ProteinsIntrinsic FactorOvo1 protein, mouseTranscription Factors

Identifiers

PMID34461129
PMCPMC9968377
OpenAlexW3197741392

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.