Evidence map›Paper›PMID 34461101›Full record

ArticleThe Journal of biological chemistry2021

DNA polymerases η and κ bypass N

Pratibha P Ghodke, F Peter Guengerich

Abstract read
In one paragraph

Article in The Journal of biological chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Pratibha P GhodkeDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
F Peter GuengerichDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, USA. Electronic address: f.guengerich@vanderbilt.edu.

Funding

BIOACTIVATION OF HALOGENATED HYDROCARBONSR01ES010546 · NIEHS · VANDERBILT UNIVERSITY · PI GUENGERICH, F PETER · 2001 to 2020
$8.1M
Mechanisms of Copying of Carcinogen-damaged DNA and RNA by Translesion PolymerasesR01ES026955 · NIEHS · VANDERBILT UNIVERSITY · PI GUENGERICH, F PETER · 2017 to 2021
$1.8M
NIEHS NIH HHS R01 ES010546NIEHS NIH HHS R01 ES026955
6 · The paper itself

Abstract

DNA-protein cross-links are formed when proteins become covalently trapped with DNA in the presence of exogenous or endogenous alkylating agents. If left unrepaired, they inhibit transcription as well as DNA unwinding during replication and may result in genome instability or even cell death. The DNA repair protein O

Indexed as

Alkyl and Aryl TransferasesDNADNA-Directed DNA PolymeraseHumansPeptidesY-Family DNA PolymerasesAlkyl and Aryl TransferasesDNADNA alkyltransferaseDNA-Directed DNA PolymerasePeptidesPOLK protein, humanPOLN protein, humanY-Family DNA PolymerasesDNA cross-linkDNA damageDNA damage responseDNA enzyme;DNA–peptide cross-linkDNA polymeraseDNA–protein cross-linkDNA–protein interactionDNA repairfidelity of DNA synthesis

Identifiers

PMID34461101
PMCPMC8463853

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.