ReviewNeuropharmacology2021
Danger and distress: Parabrachial-extended amygdala circuits.
Review in Neuropharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed.
- Early life stress induces brain-wide electrical network predisposition to migraine.The journal of headache and pain · 2026Article
- Article
- Review
- Kölliker-Fuse/Parabrachial Complex PACAP-Glutamate Pathway to the Extended Amygdala Couples Rapid Autonomic and Delayed Endocrine Responses to Acute Hypotension.International journal of molecular sciences · 2025Article
- Ex Vivo Modulation of the BNST by Parabrachial CGRP Projections Is Decreased After a History of Stress-Induced Anxiety.The European journal of neuroscience · 2025Article
- Multimodal Breathing Control: Pontomedullary Mechanisms and Current Perspectives.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- Single Inhalation of Peppermint Essential Oil Alleviates Acute Restraint Stress-Exacerbated Itch in Oxazolone-Induced Mild Dermatitis: Correlations With Brain Neuronal Activity in Female BALB/c Mouse.Brain and behavior · 2025Article
- Neuro-immune regulation of sepsis-associated delirium via the PBN-CeA-spleen axis.Journal of neuroinflammation · 2025Article
- Parabrachial calcitonin gene-related peptide neurons sex-specifically modulate behavior in anxiety assays during alcohol withdrawal.Frontiers in pharmacology · 2025Article
- Pituitary adenylate cyclase-activating polypeptide plays a role in neuropsychiatric and substance use disorders: sex-specific perspective.Frontiers in neuroscience · 2025Review
- Persistently increased post-stress activity of paraventricular thalamic neurons is essential for the emergence of stress-induced alterations in behaviour.PLoS biology · 2025Article
- Why is vestibular migraine associated with many comorbidities?Journal of neurology · 2024Review
- Article
- Functional dissection of parabrachial substrates in processing nociceptive information.Zoological research · 2024Article
- Sex-specific negative affect-like behaviour and parabrachial nucleus activation induced by BNST stimulation in adult mice with adolescent alcohol history.Addiction biology · 2024Article
- Distinct eLPBTheranostics · 2024Article
- BNST PKCδ neurons are activated by specific aversive conditions to promote anxiety-like behavior.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Review
- Parabrachial tachykinin1-expressing neurons involved in state-dependent breathing control.Nature communications · 2023Article
- Organization of neural systems expressing melanocortin-3 receptors in the mouse brain: Evidence for sexual dimorphism.The Journal of comparative neurology · 2022Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Our understanding of the role of the parabrachial nucleus (PBN) has evolved as technology has advanced, in part due to cell-specific studies and complex behavioral assays. This is reflected in the heterogeneous neuronal populations within the PBN to the extended amygdala (EA) circuits which encompass the bed nucleus of the stria terminalis (BNST) and central amygdala (CeA) circuitry, as they differentially modulate aspects of behavior in response to diverse threat-like contexts necessary for survival. Here we review how the PBN→CeA and PBN→BNST pathways differentially modulate fear-like behavior, innate and conditioned, through unique changes in neurotransmission in response to stress-inducing contexts. Furthermore, we hypothesize how in specific instances the PBN→CeA and PBN→BNST circuits are redundant and in part intertwined with their respective reciprocal projections. By deconstructing the interoceptive and exteroceptive components of affect- and stress related behavioral paradigms, evidence suggests that the PBN→CeA circuit modulates innate response to physical stimuli and fear conditioning. Conversely, the PBN→BNST circuit modulates distress-like stress in unpredictable contexts. Thereby, the PBN provides a pathway for alarming interoceptive and exteroceptive stimuli to be processed and relayed to the EA to induce stress-relevant affect. Additionally, we provide a framework for future studies to detail the cell-type specific intricacies of PBN→EA circuits in mediating behavioral responses to threats, and the relevance of the PBN in drug-use as it relates to threat and negative reinforcement. This article is part of the special Issue on 'Neurocircuitry Modulating Drug and Alcohol Abuse'.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.