Evidence map›Paper›PMID 34461062›Full record

ArticleThe Journal of pediatrics2021

Behavioral Health Diagnoses in Youth with Differences of Sex Development or Congenital Adrenal Hyperplasia Compared with Controls: A PEDSnet Study.

Rachel Sewell, Cindy L Buchanan, Shanlee Davis, Dimitri A Christakis, Amanda Dempsey, Anna Furniss, Anne E Kazak, Anna J Kerlek, Brianna Magnusen, Nathan M Pajor and 6 more

Abstract read
In one paragraph

Article in The Journal of pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Long-term outcomes in non-CAH 46,XX DSD.Frontiers in endocrinology · 2024
    Review
  11. Screening for Anxiety and Depression in Children with Congenital Adrenal HyperplasiaJournal of clinical research in pediatric endocrinology · 2023
    Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Rachel SewellDepartment of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO.
Cindy L BuchananDepartment of Psychiatry, University of Colorado Anschutz Medical Campus, Aurora, CO.
Shanlee DavisDivision of Endocrinology, Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO.
Dimitri A ChristakisSeattle Children's Research Institute, Center for Child Health, Behavior & Development, Seattle, WA.
Amanda DempseyMerck and Co., Kenilworth, NJ.
Anna FurnissUniversity of Colorado Anschutz Medical Campus, Adult & Child Consortium for Health Outcomes Research & Delivery, Aurora, CO.
Anne E KazakNemours Children's Health, Department of Pediatrics, Center for Healthcare Delivery Science and Thomas Jefferson University, Wilmington, DE.
Anna J KerlekDepartment of Psychiatry and Behavioral Health, Nationwide Children's Hospital, Columbus, OH.
Brianna MagnusenNationwide Children's Hospital, Institute for Informatics, Columbus, OH.
Nathan M PajorCincinnati Children's Hospital Medical Center, Division of Pulmonary Medicine and University of Cincinnati College of Medicine, Department of Pediatrics, Cincinnati, OH.
Laura PyleDivision of Endocrinology, Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO.
Louise C PyleDivision of Human Genetics, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA.
Hanieh RazzaghiDepartment of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA.
Beth I SchwartzNemours Children's Health, Department of Pediatrics and Thomas Jefferson University, Department of Obstetrics and Gynecology, Wilmington, DE.
Maria G VogiatziDivision of Endocrinology and Diabetes, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA.
Natalie J NokoffDivision of Endocrinology, Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO. Electronic address: Natalie.Nokoff@childrenscolorado.org.

Funding

Institutional Clinical and Translational Science AwardKL2TR001879 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI MEAGHER, EMMA ANNE · 2016 to 2025
$13.7M
UCHSC: Building Interdisciplinary Research Careers in Women's HealthK12HD057022 · NICHD · UNIVERSITY OF COLORADO DENVER · PI REGENSTEINER, JUDITH G., SANTORO, NANETTE F. · 2007 to 2023
$8.5M
The Colorado Building Interdisciplinary Research Careers in Women's Health ProgramK12AR084226 · NIAMS · UNIVERSITY OF COLORADO DENVER · PI JUDITH G. REGENSTEINER, Nanette F. Santoro · 2023 to 2026
$2.5M
Mechanisms and Fetal Origins Underlying Gonadal Germ Cell Tumor-AWARDEDK08CA248704 · NCI · CHILDREN'S RESEARCH INSTITUTE · PI PYLE, LOUISE CLARE · 2020 to 2024
$1.1M
TESTO: Testosterone Effects on Short-Term Outcomes in Infants with XXYK23HD092588 · NICHD · UNIVERSITY OF COLORADO DENVER · PI DAVIS, SHANLEE · 2017 to 2021
$826k
Population Health in Pediatric Sex Chromosome AneuploidiesR03HD102773 · NICHD · UNIVERSITY OF COLORADO DENVER · PI DAVIS, SHANLEE · 2020 to 2021
$156k
NCATS NIH HHS KL2 TR001879NCI NIH HHS K08 CA248704NIAMS NIH HHS K12 AR084226NICHD NIH HHS K12 HD057022NICHD NIH HHS K23 HD092588NICHD NIH HHS R03 HD102773
6 · The paper itself

Abstract

objectiveTo evaluate the odds of a behavioral health diagnosis among youth with differences of sex development (DSD) or congenital adrenal hyperplasia (CAH) compared with matched controls in the PEDSnet database. STUDY

designAll youth with a diagnosis of DSD (n = 1216) or CAH (n = 1647) and at least 1 outpatient encounter were extracted from the PEDSnet database and propensity-score matched on 8 variables (1:4) with controls (n = 4864 and 6588, respectively) using multivariable logistic regression. The likelihood of having behavioral health diagnoses was examined using generalized estimating equations.

resultsYouth with DSD had higher odds of a behavioral health diagnosis (OR, 1.7; 95% CI, 1.4-2.1; P < .0001) and neurodevelopmental diagnosis (OR, 1.7; 95% CI, 1.4, 2.0; P < .0001) compared with matched controls. Youth with CAH did not have an increased odds of a behavioral health diagnosis (OR, 1.0; 95% CI, 0.9, 1.1; P = .9) compared with matched controls but did have higher odds of developmental delay (OR, 1.8; 95% CI, 1.4, 2.4; P < .0001).

conclusionsYouth with DSD diagnosis have higher odds of a behavioral health or neurodevelopmental diagnosis compared with matched controls. Youth with CAH have higher odds of developmental delay, highlighting the need for screening in both groups.

Indexed as

AdolescentAdrenal Hyperplasia, CongenitalCase-Control StudiesChildChild Behavior DisordersChild, PreschoolDatabases, FactualDevelopmental DisabilitiesDisorders of Sex DevelopmentElectronic Health RecordsFemaleHumansInfantInfant, NewbornLogistic ModelsMaleanxietycongenital adrenal hyperplasiadepressiondevelopmental delaydifference of sex developmentdisorder of sex developmentintellectual disabilityneurodevelopmentalpsychiatric

Identifiers

PMID34461062
PMCPMC8604751

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.