Evidence map›Paper›PMID 34460934›Full record

ArticleNicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco2022

First E-Cigarette Flavor and Device Type Used: Associations With Vaping Persistence, Frequency, and Dependence in Young Adults.

James D Sargent, Mike Stoolmiller, Hongying Dai, Jessica L Barrington-Trimis, Rob McConnell, Janet Audrain-McGovern, Adam M Leventhal

Open access · greenAbstract read
In one paragraph

Article in Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. What is the Addictive Potential from Vaping?Nordisk alkohol- & narkotikatidskrift : NAT · 2026
    Article
  5. Patterns of ENDS-Related Content Exposure on Social Media Among US Adolescents and Young Adults.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2026
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  18. A Patchy Prohibition: Product and Flavor Substitution After the Food and Drug Administration's Prioritized Enforcement Policy on Flavored E-cigarettes.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

James D SargentC. Everett Koop Institute at Dartmouth, Geisel School of Medicine, Hanover, NH, USA.
Mike StoolmillerOregon Research Institute, Eugene, OR, USA.
Hongying DaiDepartment of Biostatistics, College of Public Health, University of Nebraska Medical Center, Omaha, NE, USA.ORCID 0000-0003-1395-7904
Jessica L Barrington-TrimisDepartment of Preventive Medicine, University of Southern California, Los Angeles, CA, USA.
Rob McConnellDepartment of Preventive Medicine, University of Southern California, Los Angeles, CA, USA.
Janet Audrain-McGovernDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Adam M LeventhalDepartment of Preventive Medicine, University of Southern California, Los Angeles, CA, USA.
University of Southern California · USDartmouth College · USOregon Research Institute · USUniversity of Nebraska Medical Center · USUniversity of Pennsylvania · US

Funding

USC Tobacco Center of Regulatory ScienceU54CA180905 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Adam Matthew Leventhal · 2018 to 2026
$39.0M
Vaping Nicotine and Cannabis Across Adolescence and Young AdulthoodR01CA229617 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BARRINGTON-TRIMIS, JESSICA LOUISE, LEVENTHAL, ADAM MATTHEW · 2019 to 2024
$4.3M
Tobacco Use Treatment Research for Vulnerable PopulationsK24DA048160 · NIDA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Adam Matthew Leventhal · 2019 to 2026
$1.4M
Understanding Transitions from Vaping to Smoking Across AdolescenceK01DA042950 · NIDA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BARRINGTON-TRIMIS, JESSICA LOUISE · 2017 to 2021
$1.0M
FDA HHSNCI NIH HHS R01 CA229617NCI NIH HHS U54 CA180905NIDA NIH HHS K01 DA042950NIDA NIH HHS K24 DA048160
6 · The paper itself

Abstract

introductionType of e-cigarette flavoring and device during first use might differentiate later e-cigarette use and dependence. This retrospective cross-sectional study examined associations of recalled first nicotine vaping device and flavor used with current vaping frequency/dependence. AIMS AND

methodsA young adult cohort from Los Angeles, California, USA completed web-based surveys (N = 2553). Using cross-sectional data from 971 reporting ever vaping nicotine, multivariable hurdle regressions tested associations between recalled first flavor (fruit/sweet, menthol/mint, other) and device (Juul, disposable, mod, box, pod, pen, other) vaped with past-30-day vaping status (yes/no) and frequency (1-30 days), and with any vaping dependence symptoms (yes/no) and count (1-10 symptoms).

resultsThe most common first-flavor was sweet (71%); the most common first-device was a vape pen (37%), then Juul (22%). First-flavor of mint/menthol (vs. other; adjusted odds ratio [AOR]: 2.22[95% CI = 1.16 to 4.25]), and first-device mod (AOR = 2.40[95% CI = 1.34 to 4.31]) and non-Juul pod (2.64[95% CI = 1.41 to 4.92]) (vs. pen) were associated with past-30-day vaping, and twice as many vaping days (adjusted rate ratios [ARRs] range: 1.96-2.12; ps < .05). First flavor of mint/menthol (vs. other; AOR: 1.95[95% CI = 1.003 to 3.79) and first device mod, box, non-Juul pod, and other (AORs range: 2.36-4.01; ps < .05) were associated with nicotine dependence. First device Juul, mod, box, and non-Juul pod were also associated with more dependence symptoms (ARRs range:1.38-1.59; ps < .05).

conclusionsExposure to mint/menthol and certain devices (mod, box, Juul, and non-Juul pods) at first e-cigarette use may be associated with more frequent e-cigarette use and nicotine dependence symptoms in young adulthood. Mint/menthol and certain devices warrant consideration in regulation of e-cigarettes based on product characteristics. IMPLICATIONS: Characteristics (flavor and device type) of first e-cigarette product used were associated with higher usage and more dependence. Pending replication with prospective designs, the findings suggest certain flavors (mint/menthol) and devices (pods, mods) merit consideration in regulation because of their possible link with continued use and dependence among young people.

Indexed as

Electronic Nicotine Delivery SystemsTobacco ProductsVapingAdolescentAdultCross-Sectional StudiesFlavoring AgentsHumansProspective StudiesRetrospective StudiesYoung AdultFlavoring Agents

Identifiers

PMID34460934
PMCPMC8842392
OpenAlexW3198909392

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.