ArticlePLoS genetics2021
Multitrait GWAS to connect disease variants and biological mechanisms.
Article in PLoS genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analysis of six dairy cattle breeds reveals biologically relevant candidate genes for mastitis resistance.Genetics, selection, evolution : GSE · 2024Pooled it
- Genetic factor analysis for characterizing phenome-wide patterns of genetic pleiotropy.Nature genetics · 2026Article
- Multi-trait polygenic scores for COPD and COPD exacerbations implicate druggable proteins.JCI insight · 2026Article
- Genomics of drug target prioritization for complex diseases.Nature reviews. Genetics · 2026Review
- Review
- Targeted analysis of dyslexia-associated regions on chromosomes 6, 12 and 15 in large multigenerational cohorts.PloS one · 2025Article
- Multi-trait GWAS identifies pleiotropic loci associated with colorectal cancer in East Asian populations.Frontiers in genetics · 2025Article
- Joint testing of rare variant burden scores using non-negative least squares.American journal of human genetics · 2024Article
- The goldmine of GWAS summary statistics: a systematic review of methods and tools.BioData mining · 2024Article
- Trait selection strategy in multi-trait GWAS: Boosting SNP discoverability.HGG advances · 2024Article
- MANOCCA: a robust and computationally efficient test of covariance in high-dimension multivariate omics data.Briefings in bioinformatics · 2024Article
- Multi-trait GWAS for diverse ancestries: mapping the knowledge gap.BMC genomics · 2024Article
- Joint regression analysis of multiple traits based on genetic relationships.Bioinformatics advances · 2024Article
- Trait selection strategy in multi-trait GWAS: Boosting SNPs discoverability.bioRxiv : the preprint server for biology · 2023Article
- GWAS for the composite traits of hematuria and albuminuria.Scientific reports · 2023Article
- Prioritization of therapeutic targets for dyslipidemia using integrative multi-omics and multi-trait analysis.Cell reports. Medicine · 2023Article
- Using Drosophila to identify naturally occurring genetic modifiers of amyloid beta 42- and tau-induced toxicity.G3 (Bethesda, Md.) · 2023Article
- Genetic Determinants of the Acute Respiratory Distress Syndrome.Journal of clinical medicine · 2023Review
- mBAT-combo: A more powerful test to detect gene-trait associations from GWAS data.American journal of human genetics · 2023Article
- mGWAS-Explorer: Linking SNPs, Genes, Metabolites, and Diseases for Functional Insights.Metabolites · 2022Article
Corrections and comments
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Authors and funding
17 authors.
Funding
Abstract
Genome-wide association studies (GWASs) have uncovered a wealth of associations between common variants and human phenotypes. Here, we present an integrative analysis of GWAS summary statistics from 36 phenotypes to decipher multitrait genetic architecture and its link with biological mechanisms. Our framework incorporates multitrait association mapping along with an investigation of the breakdown of genetic associations into clusters of variants harboring similar multitrait association profiles. Focusing on two subsets of immunity and metabolism phenotypes, we then demonstrate how genetic variants within clusters can be mapped to biological pathways and disease mechanisms. Finally, for the metabolism set, we investigate the link between gene cluster assignment and the success of drug targets in randomized controlled trials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.