Evidence map›Paper›PMID 34460330›Full record

ArticleMolecular and cellular biology2021

Regulation of Estradiol Synthesis by Aromatase Interacting Partner in Breast (AIPB).

Himangshu S Bose, Randy M Whittal, Curtis E Lanier, Brendan Marshall, Maheshinie Rajapaksha, Brian W Wheeler, Nicholas D Carbo, Elin M Hahn, Elizabeth W Perry, Neal M Hall and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular and cellular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 3 countries.

Himangshu S BoseBiomedical Sciences, Mercer Universitygrid.259906.1grid.259907.0 School of Medicine, Savannah, Georgia, USA.ORCID 0000-0002-9102-6876
Randy M WhittalDepartment of Chemistry, University of Albertagrid.17089.37, Edmonton, Alberta, Canada.
Curtis E LanierBiomedical Sciences, Mercer Universitygrid.259906.1grid.259907.0 School of Medicine, Savannah, Georgia, USA.
Brendan MarshallCell Biology and Pathology, Augusta University, Augusta, Georgia, USA.
Maheshinie RajapakshaBiomedical Sciences, Mercer Universitygrid.259906.1grid.259907.0 School of Medicine, Savannah, Georgia, USA.
Brian W WheelerBiomedical Sciences, Mercer Universitygrid.259906.1grid.259907.0 School of Medicine, Savannah, Georgia, USA.
Nicholas D CarboBiomedical Sciences, Mercer Universitygrid.259906.1grid.259907.0 School of Medicine, Savannah, Georgia, USA.
Elin M HahnBiomedical Sciences, Mercer Universitygrid.259906.1grid.259907.0 School of Medicine, Savannah, Georgia, USA.
Elizabeth W PerryCell Biology and Pathology, Augusta University, Augusta, Georgia, USA.
Neal M HallBiomedical Sciences, Mercer Universitygrid.259906.1grid.259907.0 School of Medicine, Savannah, Georgia, USA.
Mikhail M MelomedBiomedical Sciences, Mercer Universitygrid.259906.1grid.259907.0 School of Medicine, Savannah, Georgia, USA.
Edward L PerkinsBiomedical Sciences, Mercer Universitygrid.259906.1grid.259907.0 School of Medicine, Savannah, Georgia, USA.
William E BurakBiomedical Sciences, Mercer Universitygrid.259906.1grid.259907.0 School of Medicine, Savannah, Georgia, USA.
Mercer University · USAugusta University · USUniversity of Alberta · CA

Funding

Mechanism of action of steroidogenic acute regulatory protein (StAR)R01HD057876 · NICHD · MERCER UNIVERSITY MACON · PI BOSE, HIMANGSHU S · 2009 to 2013
$1.5M
NICHD NIH HHS R01 HD057876
6 · The paper itself

Abstract

Estradiol is essential for the development of female sex characteristics and fertility. Postmenopausal women and breast cancer patients have high levels of estradiol. Aromatase catalyzes estradiol synthesis; however, the factors regulating aromatase activity are unknown. We identified a new 22-kDa protein, aromatase interacting partner in breast (AIPB), from the endoplasmic reticulum of human breast tissue. AIPB expression is reduced in tumorigenic breast and further reduced in triple-negative tumors. Like that of aromatase, AIPB expression is induced by nonsteroidal estrogen. We found that AIPB and aromatase interact in nontumorigenic and tumorigenic breast tissues and cells. In tumorigenic cells, conditional AIPB overexpression decreased estradiol, and blocking AIPB availability with an AIPB-binding antibody increased estradiol. Estradiol synthesis is highly increased in AIPB knockdown cells, suggesting that the newly identified AIPB protein is important for aromatase activity and a key modulator of estradiol synthesis. Thus, a change in AIPB protein expression may represent an early event in tumorigenesis and be predictive of an increased risk of developing breast cancer.

Indexed as

Amino Acid SequenceAromataseBreastBreast NeoplasmsCell Line, TumorCell Transformation, NeoplasticEndoplasmic ReticulumEstradiolFemaleGene Expression Regulation, NeoplasticHumansMCF-7 CellsNeoplasm ProteinsProgesteroneRNA InterferenceRNA, Small InterferingAIPB protein, humanAromataseEstradiolNeoplasm ProteinsProgesteroneRNA, Small Interferingaromatasebreast cancerendoplasmic reticulumestradiolprogesteronetumorigenesis

Identifiers

PMID34460330
PMCPMC8547419
OpenAlexW3198333616

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.