ArticleJournal of bacteriology2021
Defining the Expression, Production, and Signaling Roles of Specialized Metabolites during Bacillus subtilis Differentiation.
Article in Journal of bacteriology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Understanding bacterial biofilms: From definition to treatment strategies.Frontiers in cellular and infection microbiology · 2023Pooled it
- Rethinking Microbial Chemical Ecology: Secondary Metabolites as Concentration-Dependent Signaling Hubs with Implications for Anti-Virulence Intervention.Microorganisms · 2026Review
- The microbiota of wooden cheese-ripening boards is a rich source of antimicrobial-producing bacteria againstMicrobiology spectrum · 2026Article
- Regulatory rewiring drives intraspecies competition in Bacillus subtilis.PLoS genetics · 2026Article
- Modulation of the Sporulation Dynamics in the Plant-Probiotic Bacillus velezensis 83 via Carbon and Quorum-Sensing Metabolites.Probiotics and antimicrobial proteins · 2025Article
- Thermal and shear stress-induced phenotypic changes in Bacillus paralicheniformis TB197 in submerged liquid cultures.Applied microbiology and biotechnology · 2025Article
- Article
- Subtilosin A production is influenced by surfactin levels inmicroLife · 2025Article
- A phosphate starvation induced small RNA promotes Bacillus biofilm formation.NPJ biofilms and microbiomes · 2024Article
- Rooting for success: Evolutionary enhancement of Bacillus for superior plant colonization.Microbial biotechnology · 2024Review
- Surfactin inhibits Fusarium graminearum by accumulating intracellular ROS and inducing apoptosis mechanisms.World journal of microbiology & biotechnology · 2023Review
- Extensive cellular multi-tasking withinmSystems · 2023Article
- The putative role of the epipeptide EpeX inMicrobiology (Reading, England) · 2023Article
- Nutrient Availability and Biofilm Polysaccharide Shape the Bacillaene-Dependent Antagonism of Bacillus subtilis against Salmonella Typhimurium.Microbiology spectrum · 2022Article
- The Intertwined Roles of Specialized Metabolites within the Bacillus subtilis Biofilm.Journal of bacteriology · 2021Article
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Authors and funding
6 authors at 2 institutions in 1 country.
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Abstract
Bacterial specialized (or secondary) metabolites are structurally diverse molecules that mediate intra- and interspecies interactions by altering growth and cellular physiology and differentiation. Bacillus subtilis, a Gram-positive model bacterium commonly used to study biofilm formation and sporulation, has the capacity to produce more than 10 specialized metabolites. Some of these B. subtilis specialized metabolites have been investigated for their role in facilitating cellular differentiation, but only rarely has the behavior of multiple metabolites been simultaneously investigated. In this study, we explored the interconnectivity of differentiation (biofilm and sporulation) and specialized metabolites in B. subtilis. Specifically, we interrogated how development influences specialized metabolites and vice versa. Using the sporulation-inducing medium DSM, we found that the majority of the specialized metabolites examined are expressed and produced during biofilm formation and sporulation. Additionally, we found that six of these metabolites (surfactin, ComX, bacillibactin, bacilysin, subtilosin A, and plipastatin) are necessary signaling molecules for proper progression of B. subtilis differentiation. This study further supports the growing body of work demonstrating that specialized metabolites have essential physiological functions as cell-cell communication signals in bacteria.
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