Evidence map›Paper›PMID 34460304›Full record

ArticleAntimicrobial agents and chemotherapy2021

The Novel bis-1,2,4-Triazine MIPS-0004373 Demonstrates Rapid and Potent Activity against All Blood Stages of the Malaria Parasite.

Katherine M Ellis, Leonardo Lucantoni, Marina Chavchich, Matthew Abraham, Amanda De Paoli, Madeline R Luth, Anne-Marie Zeeman, Michael J Delves, Fernando Sánchez-Román Terán, Ursula Straschil and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Systematic in vitro evolution inScience (New York, N.Y.) · 2024
    Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Katherine M EllisDrug Delivery Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash Universitygrid.1002.3, Parkville, VIC, Australia.
Leonardo LucantoniDiscovery Biology, Griffith Universitygrid.1022.1, Nathan, QLD, Australia.
Marina ChavchichThe Department of Drug Evaluation, Australian Defence Force Malaria and Infectious Disease Institute, Brisbane, QLD, Australia.ORCID 0000-0002-8142-8468
Matthew AbrahamSchool of Medicine, University of California, San Diegogrid.266100.3, La Jolla, California, USA.
Amanda De PaoliDrug Delivery Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash Universitygrid.1002.3, Parkville, VIC, Australia.
Madeline R LuthSchool of Medicine, University of California, San Diegogrid.266100.3, La Jolla, California, USA.
Anne-Marie ZeemanDepartment of Parasitology, Biomedical Primate Research Centregrid.11184.3d, Rijswijk, Netherlands.
Michael J DelvesDepartment of Life Sciences, Imperial College Londongrid.7445.2, South Kensington, London, United Kingdom.
Fernando Sánchez-Román TeránDepartment of Life Sciences, Imperial College Londongrid.7445.2, South Kensington, London, United Kingdom.
Ursula StraschilDepartment of Life Sciences, Imperial College Londongrid.7445.2, South Kensington, London, United Kingdom.
Jake BaumDepartment of Life Sciences, Imperial College Londongrid.7445.2, South Kensington, London, United Kingdom.ORCID 0000-0002-0275-352X
Clemens H M KockenDepartment of Parasitology, Biomedical Primate Research Centregrid.11184.3d, Rijswijk, Netherlands.
Stuart A RalphDepartment of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, VIC, Australia.ORCID 0000-0003-0114-7808
Elizabeth A WinzelerSchool of Medicine, University of California, San Diegogrid.266100.3, La Jolla, California, USA.
Vicky M AveryDiscovery Biology, Griffith Universitygrid.1022.1, Nathan, QLD, Australia.
Michael D EdsteinThe Department of Drug Evaluation, Australian Defence Force Malaria and Infectious Disease Institute, Brisbane, QLD, Australia.
Jonathan B BaellMedicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash Universitygrid.1002.3, Parkville, VIC, Australia.
Darren J CreekDrug Delivery Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash Universitygrid.1002.3, Parkville, VIC, Australia.ORCID 0000-0001-7497-7082

Funding

Training Program in Basic Clinical GeneticsT32GM008666 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HAMILTON, BRUCE A · 1998 to 2021
$8.6M
Discovery of long-acting, chemoprotective antimalarial compoundsR01AI152533 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WINZELER, ELIZABETH A · 2020 to 2024
$3.5M
Department of Health, Australian Government | National Health and Medical Research Council (NHMRC) APP1102147Department of Health, Australian Government | National Health and Medical Research Council (NHMRC) APP1117602Department of Health, Australian Government | National Health and Medical Research Council (NHMRC) APP1148700Medicines for Malaria Venture (MMV)NIAID NIH HHS R01 AI152533NIGMS NIH HHS T32 GM008666Wellcome 100993/Z/13/ZWellcome Trust
6 · The paper itself

Abstract

Novel bis-1,2,4-triazine compounds with potent

Indexed as

MalariaParasitesAnimalsMalePlasmodium bergheiTriazines1,2,4-triazineTriazinesantimalarialmalariaPlasmodiumtriazine

Identifiers

PMID34460304
PMCPMC8522748

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.