Evidence map›Paper›PMID 34460263›Full record

ArticleJournal of medicinal chemistry2021

Rational Design and Experimental Analysis of Short-Oligonucleotide Substrate Specificity for Targeting Bacterial Nucleases.

Tania Jiménez, Juliana Botero, Dorleta Otaegui, Javier Calvo, Frank J Hernandez, Eider San Sebastian

Abstract read
In one paragraph

Article in Journal of medicinal chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. PROTACs in the Management of Prostate Cancer.Molecules (Basel, Switzerland) · 2023
    Review
  3. Ultra-Sensitive and Specific Detection ofDiagnostics (Basel, Switzerland) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tania JiménezSomaprobes S.L, Mikeletegi Pasealekua, 83, 20009 Donostia, Gipuzkoa, Spain.
Juliana BoteroSomaprobes S.L, Mikeletegi Pasealekua, 83, 20009 Donostia, Gipuzkoa, Spain.
Dorleta OtaeguiCenter for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA), San Sebastian 20014, Spain.
Javier CalvoCenter for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA), San Sebastian 20014, Spain.
Frank J HernandezWallenberg Center for Molecular Medicine (WCMM), 58185 Linköping, Sweden.ORCID 0000-0001-6308-8087
Eider San SebastianApplied Chemistry Department, University of the Basque Country (UPV/EHU), 20018 San Sebastián, Spain.ORCID 0000-0001-9263-9626

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An undecamer oligonucleotide probe based on a pair of deoxythymidines flanked by several modified nucleotides is a specific and highly efficient biosensor for micrococcal nuclease (MNase), an endonuclease produced by

Indexed as

Drug DesignBacterial ProteinsBiosensing TechniquesChromatography, LiquidDeoxyribonucleasesMass SpectrometryModels, MolecularMolecular Docking SimulationNucleic Acid ConformationOligonucleotidesProtein ConformationStaphylococcus aureusSubstrate SpecificityBacterial ProteinsDeoxyribonucleasesOligonucleotides

Identifiers

PMID34460263
PMCPMC8436206

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.