Evidence map›Paper›PMID 34460260›Full record

ArticleJournal of natural products2021

Dual Role of Phenyl Amides from Hempseed on BACE 1, PPARγ, and PGC-1α in N2a-APP Cells.

Julio Rea Martinez, Gordana Šelo, María Ángeles Fernández-Arche, Beatriz Bermudez, María Dolores García-Giménez

Open access · hybridAbstract read
In one paragraph

Article in Journal of natural products, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Julio Rea MartinezDepartment of Pharmacology, Faculty of Pharmacy, University of Seville, 41012 Sevilla, Spain.ORCID 0000-0001-9877-3279
Gordana ŠeloDepartment of Process Engineering, Faculty of Food Technology, Josip Juraj Strossmayer University of Osijek, 31000 Osijek, Croatia.
María Ángeles Fernández-ArcheDepartment of Pharmacology, Faculty of Pharmacy, University of Seville, 41012 Sevilla, Spain.
Beatriz BermudezDepartment of Cellular Biology, Faculty of Biology, University of Seville, 41012 Sevilla, Spain.
María Dolores García-GiménezDepartment of Pharmacology, Faculty of Pharmacy, University of Seville, 41012 Sevilla, Spain.
Universidad de Sevilla · ESUniversity of Osijek · HR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In Alzheimer's disease (AD) the accumulation of amyloid β (Aβ) plaques in the brain leads to neuroinflammation, neuronal cell dysfunction, and progressive memory loss. Therefore, blocking the formation of Aβ plaques has emerged as one of the most promising strategies to develop AD treatments. Hempseed is widely used as a food, and recently its compounds have shown beneficial effects on neuroinflammation. The objective of this study was to investigate whether a fraction rich in phenyl amide compounds,

Indexed as

Amyloid Precursor Protein SecretasesAspartic Acid EndopeptidasesPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPPAR gammaAlzheimer DiseaseAmidesAmyloid beta-PeptidesAnimalsCannabisCell LineGene ExpressionMiceMolecular StructurePhytochemicalsSeedsSpainAmidesAmyloid beta-PeptidesAmyloid Precursor Protein SecretasesAspartic Acid EndopeptidasesBace1 protein, mousePeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPhytochemicalsPPAR gammaTyramine

Identifiers

PMID34460260
PMCPMC8610369
OpenAlexW3197272374

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.