ArticleAngewandte Chemie (International ed. in English)2021
Pyrrole Hemithioindigo Antimitotics with Near-Quantitative Bidirectional Photoswitching that Photocontrol Cellular Microtubule Dynamics with Single-Cell Precision*.
Article in Angewandte Chemie (International ed. in English), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 66 citations in OpenAlex.
- Benchmark Reference Data and Computational Protocols for Predicting Excitation Energies of Thioindigoid Photoswitches.Journal of computational chemistry · 2026Article
- Synthesis and Study of Substituted Chalcones Combined with Fluoroazobenzenes-New Photoswitches for Application in Biological Systems.Molecules (Basel, Switzerland) · 2026Article
- Conceptual expansion of photomedicine for spatiotemporal treatment methods.RSC medicinal chemistry · 2025Review
- Hemiphosphoindigos as a platform for chiroptical or water soluble photoswitching.Nature communications · 2025Article
- Regulation of microtubule dynamics and function in living cellsChemical science · 2024Article
- Recent Advances in Photoswitchable Fluorescent and Colorimetric Probes.Molecules (Basel, Switzerland) · 2024Review
- Visible Light Control over the Cytolytic Activity of a Toxic Pore-Forming Protein.ACS chemical biology · 2024Article
- Photoresponsive peptide materials: Spatiotemporal control of self-assembly and biological functions.Biophysics reviews · 2023Review
- Proton-Coupled Photochromic Hemithioindigo: Toward Photoactivated Chemical Sensing and Imaging.Analytical chemistry · 2023Article
- First-in-Class Colchicine-Based Visible Light Photoswitchable Microtubule Dynamics Disrupting Agent.Cells · 2023Article
- A cross-conjugation approach for high-performance diaryl-hemithioindigo photoswitches.Chemical science · 2023Article
- Heterocyclic Hemithioindigos: Highly Advantageous Properties as Molecular Photoswitches.Angewandte Chemie (International ed. in English) · 2022Article
- Hemipiperazines as peptide-derived molecular photoswitches with low-nanomolar cytotoxicity.Nature communications · 2022Article
- Optochemical Control of Therapeutic Agents through Photocatalyzed Isomerization.Angewandte Chemie (International ed. in English) · 2022Article
- Photopharmacology of Antimitotic Agents.International journal of molecular sciences · 2022Review
- Article
- Recent Approaches to the Identification of Novel Microtubule-Targeting Agents.Frontiers in molecular biosciences · 2022Review
- Pyrrole Hemithioindigo Antimitotics with Near-Quantitative Bidirectional Photoswitching that Photocontrol Cellular Microtubule Dynamics with Single-Cell Precision*.Angewandte Chemie (International ed. in English) · 2021Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report the first cellular application of the emerging near-quantitative photoswitch pyrrole hemithioindigo, by rationally designing photopharmaceutical PHTub inhibitors of the cytoskeletal protein tubulin. PHTubs allow simultaneous visible-light imaging and photoswitching in live cells, delivering cell-precise photomodulation of microtubule dynamics, and photocontrol over cell cycle progression and cell death. This is the first acute use of a hemithioindigo photopharmaceutical for high-spatiotemporal-resolution biological control in live cells. It additionally demonstrates the utility of near-quantitative photoswitches, by enabling a dark-active design to overcome residual background activity during cellular photopatterning. This work opens up new horizons for high-precision microtubule research using PHTubs and shows the cellular applicability of pyrrole hemithioindigo as a valuable scaffold for photocontrol of a range of other biological targets.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.