ArticleJournal of medical virology2022
High proportion of low cycle threshold value as an early indicator of COVID-19 surge.
Article in Journal of medical virology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 46 citations in OpenAlex.
- Safety, tolerability, and efficacy of intranasally-administered detoxified LTh(αK) in mild-to-moderate COVID-19 patients: A randomized, double-blinded, placebo-controlled phase 2 study.Human vaccines & immunotherapeutics · 2024Trial
- Exploratory pharmacokinetic-pharmacodynamic characterization and safety of standardizedFrontiers in pharmacology · 2026Article
- A promising therapeutic approach for post-Lassa fever sensorineural hearing loss: a case report.Oxford medical case reports · 2025Article
- The microbiome-cancer axis as a hidden contributor to early-onset tumorigenesis.Medical oncology (Northwood, London, England) · 2025Review
- Intensity of public health and social measures are associated with effectiveness of SARS-CoV-2 vaccine in test-negative study.medRxiv : the preprint server for health sciences · 2025Article
- Subgenomic RNA and Limited Cross-Reactive Neutralising Antibodies Point to Potential Improvements in SARS-CoV-2 Clinical Handling.International journal of molecular sciences · 2025Article
- Article
- Kinetics of Viral Shedding for Outbreak Surveillance of Emerging Infectious Diseases: Modeling Approach to SARS-CoV-2 Alpha and Omicron Infection.JMIR public health and surveillance · 2024Article
- Kinetics of SARS-CoV-2 Viral Load in Hospitalized Patients.Pathogens (Basel, Switzerland) · 2024Article
- Long-term trends in cycle threshold values: a comprehensive analysis of COVID-19 dynamics, viral load, and reproduction number in South Korea.Frontiers in public health · 2024Article
- A simple PCR-based quick detection of the economically important oriental fruit fly,Frontiers in plant science · 2024Article
- Proof of concept of the potential of a machine learning algorithm to extract new information from conventional SARS-CoV-2 rRT-PCR results.Scientific reports · 2023Article
- Systematic Review on the Correlation Between SARS-CoV-2 Real-Time PCR Cycle Threshold Values and Epidemiological Trends.Infectious diseases and therapy · 2023Review
- Viral skin diseases in odontocete cetaceans: gross, histopathological, and molecular characterization of selected pathogens.Frontiers in veterinary science · 2023Article
- Associations of SARS-CoV-2 cycle threshold values with age, gender, sample collection setting, and pandemic period.Revista do Instituto de Medicina Tropical de Sao Paulo · 2023Article
- Article
- Viral shedding patterns of symptomatic SARS-CoV-2 infections by periods of variant predominance and vaccination status in Gyeonggi Province, Korea.Epidemiology and health · 2023Article
- Variant-specific symptoms of COVID-19 in a study of 1,542,510 adults in England.Nature communications · 2022Article
- Oral dysbiosis and its linkage with SARS-CoV-2 infection.Microbiological research · 2022Article
- Performance evaluation of STANDARD Q COVID-19 Ag home test for the diagnosis of COVID-19 during early symptom onset.Journal of clinical laboratory analysis · 2022Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many countries in the world are experiencing a recent surge in COVID-19 cases. This is mainly attributed to the emergence of new SARS-CoV-2 variants. Genome sequencing is the only means to detect the evolving virus mutants and emerging variants. Cycle threshold values have an inverse relationship with viral load and lower Ct values are also found to be associated with increased infectivity. In this study, we propose to use Ct values as an early indicator for upcoming COVID-19 waves. A retrospective cross-sectional study was carried out to analyze the Ct values of positive samples reported during the first wave and second wave (April 2020-May 2021). Median Ct values of confirmatory genes were taken into consideration for comparison. Ct values below 25, >25-30, and >30 were categorized as high, moderate, and low viral load respectively. Our study found a significantly higher proportion of positive samples with a low Ct value (<25) across age groups and gender during the second wave of the COVID-19 pandemic. A higher proportion of positive samples with a low Ct value (high viral load) may act as an early indicator of an upcoming surge.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.