ReviewInternational journal of cancer2022
Risk-stratified strategies in population screening for colorectal cancer.
Review in International journal of cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Cross-cohort analysis identifies shared gut microbial signatures and validates microbial risk scores for colorectal cancer.Journal of translational medicine · 2025Pooled it
- A Systematic Review of Cost-Effectiveness Analyses of Colorectal Cancer Screening in Europe: Have Studies Included Optimal Screening Intensities?Applied health economics and health policy · 2023Pooled it
- Acceptability of risk stratification within population-based cancer screening from the perspective of the general public: A mixed-methods systematic review.Health expectations : an international journal of public participation in health care and health policy · 2023Pooled it
- Assessing the Feasibility and Acceptability of a Colorectal Cancer Risk Prediction Tool in Primary Care to Increase Screening Uptake in Singapore: A Multi-Methods Pilot Study.Journal of primary care & community healthTrial
- Leveraging Minimal Variables for Maximal Screening Yield: A Global Equity Perspective on Colorectal Cancer Risk Stratification.International journal of cancer · 2026Article
- Enhancing FIT-based colorectal cancer screening through risk prediction: a comparative evaluation of 17 models in a large Chinese cohort.Cancer biology & medicine · 2026Article
- Risk-based guidance for choosing fecal immunochemical test or colonoscopy in colorectal cancer screening: a modeling study.American journal of epidemiology · 2026Article
- Risk stratification in fecal immunochemical test-based colorectal cancer screening: Public acceptance and experiences with tailored invitation intervals.Preventive medicine reports · 2026Article
- Interval cancer risk after the upper age limit of screening has been reached: Informing risk stratification in FIT-based colorectal cancer screening.International journal of cancer · 2025Article
- A stratified precision screening strategy for enhancing hepatitis B- and C-associated liver cancer detection: a prospective study.Scientific reports · 2025Article
- A systems based qualitative analysis exploring the potential to implement risk stratified bowel cancer screening in England.BMC health services research · 2025Article
- Stratified/risk-based screening for colorectal cancer in the UK: an overview.Colorectal cancer · 2025Review
- Regional trends in colorectal cancer mortality in people aged 45-84 years in the US, 1999-2022.Journal of gastrointestinal oncology · 2024Article
- Impact of gout on colorectal cancer and its survival: a two-sample Mendelian randomization study.Discover oncology · 2024Article
- Public acceptability and anticipated uptake of risk-stratified bowel cancer screening in the UK: An online survey.Preventive medicine reports · 2024Article
- Targeted Screening for Cancer: Learnings and Applicability to Melanoma: A Scoping Review.Journal of personalized medicine · 2024Article
- Effectiveness of colorectal cancer screening integrating non-genetic and genetic risk: a prospective study based on UK Biobank data.Cancer biology & medicine · 2024Article
- Cancer screening programs in South-east Asia and Western Pacific.BMC health services research · 2024Review
- Potential anticancer properties and mechanisms of thymoquinone in colorectal cancer.Cancer cell international · 2023Review
- Implementation of risk stratification within bowel cancer screening: a community jury study exploring public acceptability and communication needs.BMC public health · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Colorectal cancer (CRC) screening has been demonstrated to reduce CRC incidence and mortality. However, besides such benefits, CRC screening is also associated with potential harmful effects. In an ideal world, screening would only be directed to the small proportion of the population that might potentially benefit. Risk-based screening can be seen as a first step towards this ideal world, by redistributing screening resources from low-risk to high-risk individuals. In theory, this should result in scarce resources being used in individuals who benefit most, while intensity of screening is reduced in individuals who benefit less, hence improving the benefit-harm ratio among all invitees. Available strategies that have been proposed for risk-based CRC screening include using information on age, sex, prior screening history, lifestyle and/or genetic information. Implementation of risk-based screening requires careful consideration of reliable risk prediction models, participation with screening and informed decision-making. While it is important to recognise the limitations of current approaches, available evidence suggests that it might be feasible to start planning the introduction of tailored strategies within screening programmes. Implementing risk-based screening based on age, sex and prior screening history alone would already represent a substantial improvement over current uniform screening approaches. We propose that it is time that screening programmes start there and continue striving towards more comprehensive approaches embedding primary prevention as an effective approach to lower risk for everyone.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.