Evidence map›Paper›PMID 34460077›Full record

ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2022

A longitudinal view of successful aging with HIV: role of resilience and environmental factors.

Nancy E Mayo, Marie-Josée Brouillette, Lyne Nadeau, Nandini Dendukuri, Marianne Harris, Fiona Smaill, Graham Smith, Réjean Thomas, Lesley K Fellows, Investigators from the Positive Brain Health Now Study

Abstract read
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In one paragraph

Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Health-related quality of life measures provide information on the contributors, components, and consequences of frailty in HIV: a systematic mapping review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nancy E MayoDepartment of Medicine, School of Physical and Occupational Therapy, Divisions of Clinical Epidemiology, Geriatrics and Experimental Medicine, McGill University, McGill University Health Centre (MUHC), Center for Outcomes Research and Evaluation, MUHC-RI, 5252 de Maisonneuve, Office 2B:43, Montreal, QC, H4A 3S536922, Canada. nancy.mayo@mcgill.ca.ORCID http://orcid.org/0000-0003-2066-7120
Marie-Josée BrouilletteDepartment of Psychiatry, McGill University, Chronic Viral Illness Service, McGill University Health Centre (MUHC), Infectious Diseases and Immunity in Global Health Program, MUHC-RI, Montreal, Canada.
Lyne NadeauCenter for Outcomes Research and Evaluation, MUHC-RI, 5252 de Maisonneuve, Office 2B:43, Montreal, QC, H4A 3S5, Canada.
Nandini DendukuriDepartment of Medicine, McGill University, Montreal, Canada.
Marianne HarrisDepartment of Family Practice, Faculty of Medicine, University Or British Columbia, BC Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada.
Fiona SmaillSpecial Immunology Services, McMaster University, Hamilton, ON, Canada.
Graham SmithMaple Leaf Medical Clinic, Toronto, ON, Canada.
Réjean ThomasClinique Médicale L'Actuel, Montreal, Québec, Canada.
Lesley K FellowsDepartment of Neurology & Neurosurgery, McGill University, Montreal Neurological Institute, University St. Montreal, 3801, Montreal, QC, H3A 2B4, Canada.
Investigators from the Positive Brain Health Now Study

Funding

CIHR TCO-125272
6 · The paper itself

Abstract

purposeThe purpose of this study is to estimate the extent to which people aging with HIV meet criteria for successful aging as operationalized through HRQL and maintain this status over time. A second objective is to identify factors that place people at promise for continued successful aging, including environmental and resilience factors.

methodsParticipants were members of the Positive Brain Health Now (BHN) cohort. People ≥ 50 years (n = 513) were classified as aging successfully if they were at or above norms on 7 or 8 of 8 health-related quality of life domains from the RAND-36. Group-based trajectory analysis, regression tree analysis, a form of machine learning, and logistic regression were applied to identify factors predicting successful aging.

results73 (14·2%) met criteria for successful aging at entry and did not change status over time. The most influential factor was loneliness which split the sample into two groups with the prevalence of successful aging 28·4% in the "almost never" lonely compared to 4·6% in the "sometimes/often" lonely group. Other influential factors were feeling safe, social network, motivation, stigma, and socioeconomic status. These factors identified 17 sub-groups with at least 30 members with the proportions classified as aging successfully ranging from 0 to 79·4%. The nine variables important to classifying successful aging had a predictive accuracy of 0.862. Self-reported cognition but not cognitive test performance improved this accuracy to 0.895. The two groups defined by successful aging status did not differ on age, sex or viral load, nadir and current.

conclusionThe results indicate the important role of social determinants of health in successful aging among people living with HIV.

Indexed as

AgingHIV InfectionsQuality of LifeCognitionFemaleHumansLonelinessMaleMiddle AgedMotivationSocial StigmaSocial SupportSocioeconomic FactorsClassificationDeterminants of healthHIVRegression treesResilienceSuccessful aging

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.