ArticlePlant molecular biology2021
Overexpression of nicotinamidase 3 (NIC3) gene and the exogenous application of nicotinic acid (NA) enhance drought tolerance and increase biomass in Arabidopsis.
Article in Plant molecular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 32 citations in OpenAlex.
- Comparative metabolomic profiling reveals salinity tolerance mechanisms in a rice introgression line.Metabolomics : Official journal of the Metabolomic Society · 2026Article
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- Application of Organic Nanofibers to Boost Specialized Metabolite Production and Antioxidant Potential inMetabolites · 2025Article
- Integrating metabolomics and high-throughput phenotyping to elucidate metabolic and phenotypic responses to early-season drought stress in Nordic spring wheat.BMC plant biology · 2025Article
- NAD(H) and NADP(H) in plants and mammals.Molecular plant · 2025Review
- Chemical application improves stress resilience in plants.Plant molecular biology · 2025Review
- Microalgae enhance cadmium accumulation inFrontiers in plant science · 2025Article
- Comparative metabolite profiling of salt sensitivePlant-environment interactions (Hoboken, N.J.) · 2024Article
- Metabonomic analysis to identify exometabolome changes underlying antifungal and growth promotion mechanisms of endophytic ActinobacteriumFrontiers in microbiology · 2024Article
- Physiological and Transcriptomic Analyses of the Effects of Exogenous Lauric Acid on Drought Resistance in Peach (Plants (Basel, Switzerland) · 2023Article
- Ethanol-Mediated Novel Survival Strategy against Drought Stress in Plants.Plant & cell physiology · 2022Article
- Ethanol induces heat tolerance in plants by stimulating unfolded protein response.Plant molecular biology · 2022Article
- Article
- Molecular and Physiological Responses ofInternational journal of molecular sciences · 2022Article
- Overexpression ofFrontiers in plant science · 2022Article
- Variation of vitamin B contents in maize inbred lines: Potential genetic resources for biofortification.Frontiers in nutrition · 2022Article
- Spermine-mediated metabolic homeostasis improves growth and stress tolerance in creeping bentgrass (Frontiers in plant science · 2022Article
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Authors and funding
13 authors at 6 institutions in 3 countries.
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Abstract
key messageOverexpressing Nicotinamidase 3 gene, and the exogenous application of its metabolite nicotinic acid (NA), enhance drought stress tolerance and increase biomass in Arabidopsis thaliana. With progressive global climatic changes, plant productivity is threatened severely by drought stress. Deciphering the molecular mechanisms regarding genes responsible for balancing plant growth and stress amelioration could imply multiple possibilities for future sustainable goals. Nicotinamide adenine dinucleotide (NAD) biosynthesis and recycling/ distribution is a crucial feature for plant growth. The current study focuses on the functional characterization of nicotinamidase 3 (NIC3) gene, which is involved in the biochemical conversion of nicotinamide (NAM) to nicotinic acid (NA) in the salvage pathway of NAD biosynthesis. Our data show that overexpression of NIC3 gene enhances drought stress tolerance and increases plant growth. NIC3-OX plants accumulated more NA as compared to WT plants. Moreover, the upregulation of several genes related to plant growth/stress tolerance indicates that regulating the NAD salvage pathway could significantly enhance plant growth and drought stress tolerance. The exogenous application of nicotinic acid (NA) showed a similar phenotype as the effect of overexpressing NIC3 gene. In short, we contemplated the role of NIC3 gene and NA application in drought stress tolerance and plant growth. Our results would be helpful in engineering plants with enhanced drought stress tolerance and increased growth potential.
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