Evidence map›Paper›PMID 34460003›Full record

Observational studyEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2021

The Scoli-RISK 1 results of lower extremity motor function 5 years after complex adult spinal deformity surgery.

Lawrence G Lenke, Scott L Zuckerman, Meghan Cerpa, Christopher I Shaffrey, Leah Y Carreon, Kenneth M C Cheung, Michael P Kelly, Michael G Fehlings, Christopher P Ames, Oheneba Boachie-Adjei and 9 more

Abstract readMulticenter StudyObservational Study
PubMed Publisher
In one paragraph

Observational study in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Biplanar vs. uniplanar pedicle subtraction osteotomy for rigid adult spinal deformity: trading safety for correction?European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 16 institutions in 7 countries.

Lawrence G LenkeDepartment of Orthopaedic Surgery, The Spine Hospital at New York Presbyterian, Columbia University Medical Center, New York, NY, 10032, USA. LL2989@cumc.columbia.edu.ORCID 0000-0002-5595-4958
Scott L ZuckermanDepartment of Orthopaedic Surgery, The Spine Hospital at New York Presbyterian, Columbia University Medical Center, New York, NY, 10032, USA.
Meghan CerpaDepartment of Orthopaedic Surgery, The Spine Hospital at New York Presbyterian, Columbia University Medical Center, New York, NY, 10032, USA.
Christopher I ShaffreyDuke University Medical Center, Durham, NC, USA.
Leah Y CarreonNorton Leatherman Spine Center, Louisville, KY, USA.
Kenneth M C CheungLi Ka Shing, Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong.
Michael P KellyWashington University in St. Louis, St. Louis MO, USA.
Michael G FehlingsUniversity of Toronto and Toronto Western Hospital, Toronto, ON, Canada.
Christopher P AmesUniversity of California San Francisco, San Francisco, CA, USA.
Oheneba Boachie-AdjeiThe FOCOS Hospital, Pantang West, Republic of Ghana.
Mark B DekutoskiMarshfield Clinic Eau Claire Center, Eau Claire, WI, USA.
Khaled M KebaishJohns Hopkins University, Baltimore, MD, USA.
Stephen J LewisUniversity of Toronto and Toronto Western Hospital, Toronto, ON, Canada.
Yukihiro MatsuyamaHamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.
Ferran PelliséHospital Universitari Vall D'Hebron, Barcelona, Spain.
Yong QiuAffiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China.
Frank J SchwabHospital for Special Surgery, New York, NY, USA.
Justin S SmithUniversity of Virginia, Charlottesville, VA, USA.
AO Spine Knowledge Forum Deformity and SRS Scoli-RISK-1 Study Group
Columbia University Irving Medical Center · USUniversity of Toronto · CADuke Medical Center · USHamamatsu University School of Medicine · JPHospital for Special Surgery · USJohns Hopkins University · USNanjing Drum Tower Hospital · CNNewYork–Presbyterian Hospital · USNorton Healthcare · USUniversity of California, San Francisco · USUniversity of Hong Kong · HKUniversity of Virginia · USUniversity of Wisconsin–Eau Claire · USVall d'Hebron Hospital Universitari · ESWashington University in St. Louis · USWest End Hospital · GH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionNeurologic complications after complex adult spinal deformity (ASD) surgery are important, yet outcomes are heterogeneously reported, and long-term follow-up of actual lower extremity motor function is unknown.

objectiveTo prospectively evaluate lower extremity motor function scores (LEMS) before and at 5 years after surgical correction of complex ASD.

designRetrospective analysis of a prospective, multicenter, international observational study.

methodsThe Scoli-RISK-1 study enrolled 272 ASD patients undergoing surgery from 15 centers around the world. Inclusion criteria were Cobb angle of > 80°, corrective osteotomy for congenital or revision deformity and/or 3-column osteotomy. Among patients with 5-year follow-up, comparisons of LEMS to baseline and within each follow-up period were made via documented neurologic exams on each patient.

resultsSeventy-seven (28.3%) patients had 5-year follow-up. Among these 77 patients with 5-year follow-up, rates of postoperative LEMS deterioration were: 14.3% hospital discharge, 10.7% at 6 weeks, 6.5% at 6 months, 9.5% at 2 years and 9.3% at 5 years postoperative. During the 2-5 year window, while mean LEMS did not change significantly (-0.5, p = 0.442), eight (11.1%) patients deteriorated (of which 3 were ≥ 4 motor points), and six (8.3%) patients improved (of which 2 were ≥ 4 points). Of the 14 neurologic complications, four (28.6%) were surgery-related, three of which required reoperation. While mean LEMS were not impacted in patients with a major surgery-related complication, mean LEMS were significantly lower in patients with neurologic surgery-related complications at discharge (p = 0.041) and 6 months (p = 0.008) between the two groups as well as the change from baseline to 5 years (p = 0.041).

conclusionsIn 77 patients undergoing complex ASD surgery with 5-year follow-up, while mean LEMS did not change from 2 to 5 years, subtle neurologic changes occurred in approximately 1 in 5 patients (11.1% deteriorated; 8.3% improved). Major surgery-related complication did not result in decreased LEMS; however, those with neurologic surgery-related complications continued to have decreased lower extremity motor function at 5 years postoperative. These results underscore the importance of long-term follow-up to 5 years, using individual motor scores rather than group averages, and comparing outcomes to both baseline and last follow-up.

Indexed as

Postoperative ComplicationsSpinal FusionAdultFollow-Up StudiesHumansLower ExtremityNeurosurgical ProceduresProspective StudiesRetrospective StudiesAdult spinal deformityAdult spinal deformity surgeryComplicationsLong-term follow-upLower extremity motor functionNeurologic deficitScoli-RISK-1

Identifiers

PMID34460003
OpenAlexW3196885999

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.