Evidence map›Paper›PMID 34459660›Full record

ArticleThe Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association2022

Novel GRHL3 Variants in a South African Cohort With Cleft Lip and Palate.

Thirona Naicker, Chinyere C Adeleke, Azeez Alade, Peter A Mossey, Waheed A Awotoye, Tamara D Busch, Mary Li, Joy Olotu, Lord J J Gowans, Colleen Aldous and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 5 countries.

Thirona NaickerDepartment of Paediatrics, Clinical Genetics, 72753University of KwaZulu-Natal and Inkosi Albert Luthuli Central Hospital, Durban, South Africa.ORCID 0000-0001-7146-7159
Chinyere C AdelekeDepartment of Oral Pathology, Radiology and Medicine, 573932College of Dentistry, 50699The University of Iowa, Iowa City, IA, USA.
Azeez AladeDepartment of Oral Pathology, Radiology and Medicine, 573932College of Dentistry, 50699The University of Iowa, Iowa City, IA, USA.
Peter A MosseyDepartment of Orthodontics, University of Dundee, Dundee, UK.
Waheed A AwotoyeDepartment of Oral Pathology, Radiology and Medicine, 573932College of Dentistry, 50699The University of Iowa, Iowa City, IA, USA.
Tamara D BuschDepartment of Oral Pathology, Radiology and Medicine, 573932College of Dentistry, 50699The University of Iowa, Iowa City, IA, USA.
Mary LiDepartment of Oral Pathology, Radiology and Medicine, 573932College of Dentistry, 50699The University of Iowa, Iowa City, IA, USA.
Joy OlotuDepartment of Anatomy, 327041University of Port Harcourt, Rivers State, Nigeria.
Lord J J GowansDepartment of Biochemistry and Biotechnology, 98763Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.ORCID 0000-0003-0080-9101
Colleen AldousSchool of Clinical Medicine, University of KwaZulu-Natal, Durban, South Africa.
Azeez ButaliDepartment of Oral Pathology, Radiology and Medicine, 573932College of Dentistry, 50699The University of Iowa, Iowa City, IA, USA.
University of Iowa · USKwame Nkrumah University of Science and Technology · GHSmile Train · USUniversity of Dundee · GBUniversity of KwaZulu-Natal · ZAUniversity of Port Harcourt · NG

Funding

Whole Genome Sequencing for Orofacial Clefts, Incidental Findings and Role of Community GatekeepersR01DE028300 · NIDCR · UNIVERSITY OF IOWA · PI BUTALI, AZEEZ · 2020 to 2024
$3.9M
Genetic studies of nonsyndromic clefts in populations of African Descent.R00DE022378 · NIDCR · UNIVERSITY OF IOWA · PI BUTALI, AZEEZ · 2014 to 2016
$747k
Elucidating Cleft Etiology Employing Multiplex and Twin Families (ElCEEMuTF)K43DE029427 · NIDCR · KWAME NKRUMAH UNIVERSITY/SCIENCE/TECH · PI GOWANS, LORD JEPHTHAH JOOJO · 2019 to 2023
$529k
NIDCR NIH HHS K43 DE029427NIDCR NIH HHS R00 DE022378NIDCR NIH HHS R01 DE028300
6 · The paper itself

Abstract

objectiveThe etiology of cleft palate (CP) is poorly understood compared with that of cleft lip with or without palate (CL ± P). Recently, variants in Grainyhead like transcription factor 3 (

designWe sequenced the exons of

settingThe cleft clinics from 2 public, tertiary hospitals in Durban, South Africa (SA), namely Inkosi Albert Luthuli Central Hospital and KwaZulu-Natal Children's Hospital. PATIENTS,

participantsOne hundred patients with CL ± P and their parents.

interventionsSaliva samples were collected.

main outcome measuresTo ascertain the genetic variants in the

resultsFive variants in

conclusionsThis study provides further evidence that variants in

Indexed as

Cleft LipCleft PalateChildDNA-Binding ProteinsHumansPolymorphism, Single NucleotideSouth AfricaTranscription FactorsDNA-Binding ProteinsGRHL3 protein, humanTranscription Factorscleft lip and cleft palateGRHL3South Africa

Identifiers

PMID34459660
PMCPMC9790085
OpenAlexW3198886913

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.