Evidence map›Paper›PMID 34459252›Full record

ArticleJournal of the American Heart Association2021

Ronny Alcalai, Michael Arad, Hiroko Wakimoto, Dor Yadin, Joshua Gorham, Libin Wang, Elia Burns, Barry J Maron, William C Roberts, Tetsuo Konno and 4 more

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

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  7. Rat models of musculoskeletal lysosomal storage disorders and their role in pre-clinical evaluation of gene therapy approaches.Mammalian genome : official journal of the International Mammalian Genome Society · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 2 countries.

Ronny AlcalaiHeart InstituteHadassah Hebrew University Medical Center Jerusalem Israel.
Michael AradDivision of Cardiology Sheba Medical Centre and Tel Aviv University Ramat Gan Israel.ORCID 0000-0003-3723-7493
Hiroko WakimotoDepartment of Genetics Harvard Medical School Boston MA.
Dor YadinDivision of Cardiology Sheba Medical Centre and Tel Aviv University Ramat Gan Israel.ORCID 0000-0001-9143-0943
Joshua GorhamDepartment of Genetics Harvard Medical School Boston MA.ORCID 0000-0001-5969-4690
Libin WangDepartment of Genetics Harvard Medical School Boston MA.
Elia BurnsHeart InstituteHadassah Hebrew University Medical Center Jerusalem Israel.
Barry J MaronMinneapolis Heart Institute Foundation Minneapolis MN.ORCID 0000-0002-1710-8670
William C RobertsBaylor Heart & Vascular InstituteBaylor University Medical Center Dallas TX.ORCID 0000-0001-7735-5641
Tetsuo KonnoDepartment of Genetics Harvard Medical School Boston MA.
David A ConnerDepartment of Genetics Harvard Medical School Boston MA.
Antonio R Perez-AtaydeDepartment of Pathology Children's Hospital BostonHarvard Medical School Boston MA.ORCID 0000-0001-8036-6288
Jon G SeidmanDepartment of Genetics Harvard Medical School Boston MA.
Christine E SeidmanDepartment of Genetics Harvard Medical School Boston MA.
Harvard University · USTel Aviv University · ILBaylor University Medical Center · USBrigham and Women's Hospital · USHadassah Medical Center · ILMinneapolis Heart Institute Foundation · US

Funding

Defining Pathways from Gene Mutation to Heart FailureR01HL080494 · NHLBI · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI CHEN, CHRISTOPHER S, SEIDMAN, CHRISTINE E · 2005 to 2024
$9.4M
Molecular Signaling in Hypertrophic CardiomyopathyR01HL084553 · NHLBI · HARVARD MEDICAL SCHOOL · PI SEIDMAN, JONATHAN G · 2007 to 2022
$5.9M
Howard Hughes Medical InstituteNHLBI NIH HHS R01 HL084553
6 · The paper itself

Abstract

Background Human mutations in the X-linked lysosome-associated membrane protein-2 (

Indexed as

Lysosomal-Associated Membrane Protein 2AnimalsArrhythmias, CardiacAutophagyCalciumCardiomegalyCardiomyopathiesGlycogen Storage Disease Type IIbHypertrophy, Left VentricularMaleMiceCalciumLysosomal-Associated Membrane Protein 2autophagycalcium transientscardiomyopathyDanon diseasemouse model

Identifiers

PMID34459252
PMCPMC8649277
OpenAlexW3198385225

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.