Evidence map›Paper›PMID 34459247›Full record

ArticleJournal of the American Heart Association2021

Prognostic Value of Angiogenic Markers in Pregnant Women With Chronic Hypertension.

Julia Binder, Pilar Palmrich, Erkan Kalafat, Petra Pateisky, Ebru Öztürk, Johanna Mittelberger, Asma Khalil

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. DEVELOPING A BEDSIDE TEST FOR PREECLAMPSIA: OVERCOMING SISYPHUS.Transactions of the American Clinical and Climatological Association · 2024
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Julia BinderDepartment of Obstetrics and Feto-Maternal Medicine Medical University of Vienna Austria.ORCID 0000-0002-5725-9270
Pilar PalmrichDepartment of Obstetrics and Feto-Maternal Medicine Medical University of Vienna Austria.ORCID 0000-0003-2449-2575
Erkan KalafatDepartment of Statistics Faculty of Arts and Sciences Middle East Technical University Ankara Turkey.
Petra PateiskyDepartment of Obstetrics and Feto-Maternal Medicine Medical University of Vienna Austria.
Ebru ÖztürkDepartment of Biostatistics Faculty of Medicine Hacettepe University Ankara Turkey.ORCID 0000-0001-9206-6856
Johanna MittelbergerDepartment of Obstetrics and Feto-Maternal Medicine Medical University of Vienna Austria.
Asma KhalilFetal Medicine Unit St George's Hospital St George's University of London London United Kingdom.ORCID 0000-0003-2802-7670
Medical University of Vienna · ATHacettepe University · TRKoç University · TRSt George's, University of London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background Women with chronic hypertension face a 5- to 6-fold increased risk of developing preeclampsia compared with normotensive women. Angiogenic markers, especially soluble fms-like kinase 1 (sFlt-1) and placental growth factor (PlGF), were identified as clinically useful markers predicting the development of preeclampsia, but data on the prediction of superimposed preeclampsia are scarce. Therefore, we aimed to evaluate the predictive value of the sFlt-1/PlGF ratio for delivery because of superimposed preeclampsia in women with chronic hypertension. Methods and Results This retrospective study included 142 women with chronic hypertension and suspected superimposed preeclampsia. Twenty-seven women (19.0%) delivered because of maternal indications only, 17 women (12.0%) because of fetal indications primarily, and 98 women (69.0%) for other reasons. Women who both delivered because of maternal indications and for fetal indications had a significantly higher sFlt-1/PlGF ratio (median 99.9 and 120.2 versus 7.3, respectively,

Indexed as

HypertensionPre-EclampsiaBiomarkersFemaleHumansPlacenta Growth FactorPregnancyPrognosisRetrospective StudiesVascular Endothelial Growth Factor Receptor-1BiomarkersFLT1 protein, humanPlacenta Growth FactorVascular Endothelial Growth Factor Receptor-1angiogenic markerschronic hypertensionpreeclampsiasuperimposed preeclampsia

Identifiers

PMID34459247
PMCPMC8649241
OpenAlexW3196673609

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.