Evidence map›Paper›PMID 34459236›Full record

ArticleJournal of the American Heart Association2021

Characteristics of Bicuspid Aortic Valve Disease and Stenosis: The National Echo Database of Australia.

Michelle S Lim, Geoff Strange, David Playford, Simon Stewart, David S Celermajer

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Bicuspid Aortic Valve and Sudden Cardiac Death.Life (Basel, Switzerland) · 2025
    Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Risk for Mortality with Increasingly Severe Aortic Stenosis: An International Cohort Study.Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Michelle S LimUniversity of SydneySydney Medical SchoolFaculty of Medicine and Health Camperdown New South Wales Australia.ORCID 0000-0001-6416-5566
Geoff StrangeUniversity of SydneySydney Medical SchoolFaculty of Medicine and Health Camperdown New South Wales Australia.ORCID 0000-0001-6800-7119
David PlayfordUniversity of Notre Dame Fremantle Western Australia Australia.ORCID 0000-0003-4492-1103
Simon StewartTorrens University Australia Adelaide South Australia Australia.
David S CelermajerUniversity of SydneySydney Medical SchoolFaculty of Medicine and Health Camperdown New South Wales Australia.ORCID 0000-0001-7640-0439
The University of Sydney · AUThe University of Notre Dame Australia · AUTorrens University Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background Bicuspid aortic valve (BAV) is the most common congenital heart disease in adults but is clinically heterogeneous. We aimed to describe the echocardiographic characteristics of BAV and compare patients with BAV with moderate-to-severe aortic stenosis (AS) with those with tricuspid aortic valve (TAV) stenosis. Methods and Results Using the National Echo Database of Australia, patients in whom BAV was identified were studied. Those with moderate-to-severe AS (mean gradient >20 mm Hg [BAV-AS]) were compared with those with TAV and moderate-to-severe AS (TAV-AS). Of 264 159 adults whose aortic valve morphology was specified, 4783 (1.8%) had confirmed BAV (aged 49.6±17.4 years, 69% men). Of these, 42% had no AS, and 46% had no aortic regurgitation. Moderate-to-severe AS was detected in a greater proportion of patients with BAV with a recorded mean gradient (n=1112, 34%) compared with those with TAV (n=4377, 4%;

Indexed as

Aortic Valve StenosisBicuspid Aortic Valve DiseaseMitral Valve StenosisAdultAortic ValveConstriction, PathologicFemaleHumansMaleaortic stenosiscardiac ultrasoundmortalityregurgitation

Identifiers

PMID34459236
PMCPMC8649243
OpenAlexW3175191397

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.