ArticleAngewandte Chemie (International ed. in English)2021
Background-Free Proton NMR Spectroscopy with Radiofrequency Amplification by Stimulated Emission Radiation.
Article in Angewandte Chemie (International ed. in English), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Rapid RASER MRI.Angewandte Chemie (International ed. in English) · 2026Article
- RASER for Increased Spectral Resolution in Carbon-13 NMR.Analytical chemistry · 2025Article
- Spontaneous increasing of sensitivity and resolution in parahydrogen-induced hyperpolarization by RASER.Magnetic resonance letters · 2025Article
- Through-bond and through-space radiofrequency amplification by stimulated emission of radiation.Communications chemistry · 2024Article
- Toward Ultra-High-Quality-Factor Wireless Masing Magnetic Resonance Sensing.Angewandte Chemie (International ed. in English) · 2024Article
- Carbon-13 Radiofrequency Amplification by Stimulated Emission of Radiation of the Hyperpolarized Ketone and Hemiketal Forms of Allyl [1-ACS sensors · 2024Article
- Article
- Parahydrogen-Induced Carbon-13 Radiofrequency Amplification by Stimulated Emission of Radiation.Angewandte Chemie (International ed. in English) · 2023Article
- Through-Space Multinuclear Magnetic Resonance Signal Enhancement Induced by Parahydrogen and Radiofrequency Amplification by Stimulated Emission of Radiation.Analytical chemistry · 2022Article
- RASER MRI: Magnetic resonance images formed spontaneously exploiting cooperative nonlinear interaction.Science advances · 2022Article
- Instrumentation for Hydrogenative Parahydrogen-Based Hyperpolarization Techniques.Analytical chemistry · 2022Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
We report on the utility of Radiofrequency Amplification by Stimulated Emission Radiation (RASER) for background-free proton detection of hyperpolarized biomolecules. We performed hyperpolarization of ≈0.3 M ethyl acetate via pairwise parahydrogen addition to vinyl acetate. A proton NMR signal with signal-to-noise ratio exceeding 100 000 was detected without radio-frequency excitation at the clinically relevant magnetic field of 1.4 T using a standard (non-cryogenic) inductive detector with quality factor of Q=68. No proton background signal was observed from protonated solvent (methanol) or other added co-solvents such as ethanol, water or bovine serum. Moreover, we demonstrate RASER detection without radio-frequency excitation of a bolus of hyperpolarized contrast agent in biological fluid. Completely background-free proton detection of hyperpolarized contrast agents in biological media paves the way to new applications in the areas of high-resolution NMR spectroscopy and in vivo spectroscopy and imaging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.