ReviewThe EMBO journal2021
Autophagy in major human diseases.
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In one paragraph
Review in The EMBO journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 941 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
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941citing papers in PubMed, 1 pooled it
154.3field-weighted citation impact, top 1% of its field
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Who cites it
941 citing papers in PubMed, 1 synthesis or guideline pooled it, 1,474 citations in OpenAlex.
- Asymptomatic Versus Symptomatic Alzheimer's Disease Neuropathology: A Systematic Review of Differences Reported in Post-Mortem Studies.Neuropathology and applied neurobiology · 2026Pooled it
- Dietary Modulation of CMA: Implications for Cancer Prevention and Therapy.Physiology (Bethesda, Md.) · 2027Review
- The responsive nucleus: morphological signatures of cellular state.Nucleus (Austin, Tex.) · 2026Review
- GLIS3 promotes the malignant biological behavior of gastric cancer cells by transcriptionally regulating PNPO to influence autophagy.Medical oncology (Northwood, London, England) · 2026Article
- Mapping the Tissue Architecture and Endothelial-PEC Network in HAML Using Single-Cell and Spatial Transcriptomics.Cancer science · 2026Article
- Decline of chaperone-mediated autophagy in aging impairs macrophage clearance of senescent cells.Nature aging · 2026Article
- Autophagy and selective autophagy receptors: Key players against Alzheimer's disease.Neural regeneration research · 2026Article
- Proteostasis and ageing dissidence.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026Review
- Defective autophagy in diabetic nephropathy sensitizes podocytes to hyperuricemia induced injury by amplifying inflammasome activation.Clinical and experimental nephrology · 2026Article
- Autophagy: Mechanisms and therapeutic perspectives in intestinal metaplasia (Review).Molecular medicine reports · 2026Review
- ATG8 protein clustering: a HOTS topic in autophagy.EMBO reports · 2026Article
- Article
- REDD1 Silencing Aggravates Aortic Dissection and Promotes VSMC Apoptosis with Autophagy-Related Changes.Biomedicines · 2026Article
- The Hallmarks of Aging: From Molecular Mechanisms to Clinical Translation.International journal of molecular sciences · 2026Review
- 1,2-Dichloroethane Induces Neuronal Apoptosis Through AMPK-mTOR-ULK1 Pathway Activation and Autophagic Flux Impairment.Biology · 2026Article
- Canonical and noncanonical autophagy in immunity.Immunity · 2026Review
- The neuroprotective potential of thymoquinone and intermittent fasting on aluminum chloride-induced Alzheimer's disease like model in rat hippocampus: insights into neurogenesis and autophagy.Journal of molecular histology · 2026Article
- Organelle Crosstalk and Metabolic Reprogramming in Idiopathic Pulmonary Fibrosis: Mechanisms and Therapeutic Implications.Cell biochemistry and function · 2026Review
- Orchestrating Ovarian Dysfunction- The Role of Programmed Cell Death in PCOS.Cell biochemistry and biophysics · 2026Article
- WDR81 Mutation in Two Siblings: A Case Report and Review of Literature.Molecular syndromology · 2026Article
881 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
59 authors at 20 institutions in 23 countries.
Daniel J KlionskyLife Sciences Institute, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-7828-8118
Giulia PetroniDepartment of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA.
Ravi K AmaravadiDepartment of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Eric H BaehreckeDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA, USA.
Andrea BallabioTelethon Institute of Genetics and Medicine, Pozzuoli, Italy.ORCID 0000-0003-1381-4604
Patricia BoyaMargarita Salas Center for Biological Research, Spanish National Research Council, Madrid, Spain.ORCID 0000-0003-3045-951X
José Manuel Bravo-San PedroFaculty of Medicine, Department Section of Physiology, Complutense University of Madrid, Madrid, Spain.
Ken CadwellKimmel Center for Biology and Medicine at the Skirball Institute, New York University Grossman School of Medicine, New York, NY, USA.
Francesco CecconiCell Stress and Survival Unit, Center for Autophagy, Recycling and Disease (CARD), Danish Cancer Society Research Center, Copenhagen, Denmark.ORCID 0000-0002-5614-4359
Augustine M K ChoiDivision of Pulmonary and Critical Care Medicine, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Mary E ChoiNew York-Presbyterian Hospital, Weill Cornell Medicine, New York, NY, USA.
Charleen T ChuDepartment of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID 0000-0002-5052-8271
Patrice CodognoInstitut Necker-Enfants Malades, INSERM U1151-CNRS UMR 8253, Paris, France.ORCID 0000-0002-5492-3180
Maria Isabel ColomboLaboratorio de Mecanismos Moleculares Implicados en el Tráfico Vesicular y la Autofagia-Instituto de Histología y Embriología (IHEM)-Universidad Nacional de Cuyo, CONICET- Facultad de Ciencias Médicas, Mendoza, Argentina.
Ana Maria CuervoDepartment of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY, USA.ORCID 0000-0002-0771-700X
Vojo DereticAutophagy Inflammation and Metabolism (AIM, Center of Biomedical Research Excellence, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Ivan DikicInstitute of Biochemistry II, School of Medicine, Goethe University, Frankfurt, Frankfurt am Main, Germany.ORCID 0000-0001-8156-9511
Zvulun ElazarDepartment of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, Israel.
Eeva-Liisa EskelinenInstitute of Biomedicine, University of Turku, Turku, Finland.
Gian Maria FimiaDepartment of Molecular Medicine, Sapienza University of Rome, Rome, Italy.ORCID 0000-0003-4438-3325
David A GewirtzDepartment of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA.ORCID 0000-0003-0437-4934
Douglas R GreenDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Malene HansenSanford Burnham Prebys Medical Discovery Institute, Program of Development, Aging, and Regeneration, La Jolla, CA, USA.
Marja JäätteläCell Death and Metabolism, Center for Autophagy, Recycling & Disease, Danish Cancer Society Research Center, Copenhagen, Denmark.ORCID 0000-0001-5950-7111
Terje JohansenDepartment of Medical Biology, Molecular Cancer Research Group, University of Tromsø-The Arctic University of Norway, Tromsø, Norway.ORCID 0000-0003-1451-9578
Gábor JuhászInstitute of Genetics, Biological Research Center, Szeged, Hungary.
Vassiliki KarantzaMerck & Co., Inc., Kenilworth, NJ, USA.
Claudine KraftInstitute of Biochemistry and Molecular Biology, ZBMZ, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID 0000-0002-3324-4701
Guido KroemerCentre de Recherche des Cordeliers, Equipe Labellisée par la Ligue Contre le Cancer, Université de Paris, Sorbonne Université, Inserm U1138, Institut Universitaire de France, Paris, France.ORCID 0000-0002-9334-4405
Nicholas T KtistakisSignalling Programme, Babraham Institute, Cambridge, UK.
Sharad KumarCentre for Cancer Biology, University of South Australia, Adelaide, SA, Australia.ORCID 0000-0001-7126-9814
Carlos Lopez-OtinDepartamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Universidad de Oviedo, Oviedo, Spain.ORCID 0000-0001-6964-1904
Kay F MacleodThe Ben May Department for Cancer Research, The Gordon Center for Integrative Sciences, W-338, The University of Chicago, Chicago, IL, USA.
Frank MadeoInstitute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria.
Jennifer MartinezImmunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA.
Alicia MeléndezBiology Department, Queens College, City University of New York, Flushing, NY, USA.
Noboru MizushimaDepartment of Biochemistry and Molecular Biology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.ORCID 0000-0002-6258-6444
Christian MünzViral Immunobiology, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.ORCID 0000-0001-6419-1940
Josef M PenningerInstitute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna BioCenter (VBC), Vienna, Austria.
Rushika M PereraDepartment of Anatomy, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0003-2435-2273
Mauro PiacentiniDepartment of Biology, University of Rome "Tor Vergata", Rome, Italy.ORCID 0000-0003-2919-1296
Fulvio ReggioriDepartment of Biomedical Sciences of Cells & Systems, Molecular Cell Biology Section, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.ORCID 0000-0003-2652-2686
David C RubinszteinDepartment of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.
Kevin M RyanCancer Research UK Beatson Institute, Glasgow, UK.
Junichi SadoshimaDepartment of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, Rutgers New Jersey Medical School, Newark, NJ, USA.
Laura SantambrogioDepartment of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA.
Luca ScorranoIstituto Veneto di Medicina Molecolare, Padova, Italy.ORCID 0000-0002-8515-8928
Hans-Uwe SimonInstitute of Pharmacology, University of Bern, Bern, Switzerland.
Anna Katharina SimonThe Kennedy Institute of Rheumatology, NDORMS, University of Oxford, Oxford, UK.
Anne SimonsenDepartment of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.ORCID 0000-0003-4711-7057
Alexandra StolzInstitute of Biochemistry II, School of Medicine, Goethe University, Frankfurt, Frankfurt am Main, Germany.ORCID 0000-0002-3340-439X
Nektarios TavernarakisInstitute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Heraklion, Crete, Greece.ORCID 0000-0002-5253-1466
Sharon A ToozeMolecular Cell Biology of Autophagy, The Francis Crick Institute, London, UK.ORCID 0000-0002-2182-3116
Tamotsu YoshimoriDepartment of Genetics, Graduate School of Medicine, Osaka University, Suita, Japan.ORCID 0000-0001-9787-3788
Junying YuanInterdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China.
Zhenyu YueDepartment of Neurology, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Qing ZhongKey Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Department of Pathophysiology, Shanghai Jiao Tong University School of Medicine (SJTU-SM), Shanghai, China.ORCID 0000-0001-6979-955X
Lorenzo GalluzziDepartment of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA.ORCID 0000-0003-2257-8500
Federico PietrocolaDepartment of Biosciences and Nutrition, Karolinska Institute, Huddinge, Sweden.ORCID 0000-0002-2930-234X
Cornell University · USGoethe University Frankfurt · DENewYork–Presbyterian Hospital · USUniversity of Rome Tor Vergata · ITAlbert Einstein College of Medicine · USAllen Institute for Brain Science · USBabraham Institute · GBBaylor College of Medicine · USCancer Research UK Scotland Institute · GBCentre National de la Recherche Scientifique · FRCentro de Investigaciones Biológicas Margarita Salas · ESConsejo Nacional de Investigaciones Científicas y Técnicas · AREötvös Loránd University · HUHarvard University · USInstitute of Molecular Biotechnology · ATIstituti di Ricovero e Cura a Carattere Scientifico · ITKarolinska Institutet · SEKarolinska University Hospital · SEMerck & Co., Inc., Rahway, NJ, USA (United States) · USNational Institute of Environmental Health Sciences · US
Funding
Targeting the MAP and PI3 Kinase Pathways in MelanomaP01CA114046 · NCI · WISTAR INSTITUTE · PI MURPHY, MAUREEN E. · 2008 to 2023
$37.1MRole of Autophagy in T Cell Function and Immunosenescence (Project 3)P01AG031782 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI CUERVO, ANA MARIA · 2009 to 2024
$36.2MRegulation of the Autophagy Process in Organismal AgingR01AG038664 · NIA · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI Malene Hansen · 2011 to 2026
$6.4MRegulation of autophagy during animal developmentR35GM131689 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Eric H Baehrecke · 2019 to 2026
$4.9MDYNAMICS AND TUNING OF THE MHC II PRESENTED PEPTIDOMER01AI137198 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI SANTAMBROGIO, LAURA, STERN, LAWRENCE J. · 2018 to 2022
$4.6MDECREASED PROTEIN DEGRADATION IN AGINGR01AG021904 · NIA · YESHIVA UNIVERSITY · PI CUERVO, ANA MARIA · 2003 to 2012
$3.7MFunctions of BNIP3 in lipid metabolism in the liver and in hepatocellular carcinomaR01CA200310 · NCI · UNIVERSITY OF CHICAGO · PI KAY F MACLEOD · 2016 to 2026
$3.6MTargeting the autophagy-lysosome system to block pancreatic cancerR01CA251726 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PERERA, RUSHIKA MIRIAM · 2021 to 2025
$1.8MDissecting new mechanisms of lysosome quality control in health and diseaseR01CA260249 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PERERA, RUSHIKA MIRIAM · 2021 to 2025
$1.8MTransporters, nutrient sensing and autophagyR01AG064892 · NIA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BAEHRECKE, ERIC H · 2019 to 2023
$1.7M(PQ5) Consequences of imbalanced mitophagy and mitochondrial biogenesis in cancerR01CA216242 · NCI · UNIVERSITY OF CHICAGO · PI MACLEOD, KAY F · 2017 to 2021
$1.6MRole of autophagy and retromer genes in GLP-1/Notch signalingR15GM102846 · NIGMS · QUEENS COLLEGE · PI MELENDEZ, ALICIA · 2012 to 2020
$1.2MBiotechnology and Biological Sciences Research Council BBS/E/B/000C0413Biotechnology and Biological Sciences Research Council BBS/E/B/000C0417Cancer Research UK 15816Cancer Research UK 22903Cancer Research UK 28686Medical Research Council UKDRI-2002NCI NIH HHS P01 CA114046NCI NIH HHS R01 CA200310NCI NIH HHS R01 CA216242NCI NIH HHS R01 CA251726NCI NIH HHS R01 CA260249NIAID NIH HHS R01 AI137198NIA NIH HHS P01 AG031782NIA NIH HHS R01 AG021904NIA NIH HHS R01 AG038664NIA NIH HHS R01 AG064892NIGMS NIH HHS R15 GM102846NIGMS NIH HHS R35 GM131689
Abstract
Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interventions impairing autophagy responses promote or aggravate disease in a plethora of experimental models. Consistently, mutations in autophagy-related processes cause severe human pathologies. Here, we review and discuss preclinical data linking autophagy dysfunction to the pathogenesis of major human disorders including cancer as well as cardiovascular, neurodegenerative, metabolic, pulmonary, renal, infectious, musculoskeletal, and ocular disorders.
Indexed as
AutophagyDisease SusceptibilityAnimalsBiomarkersGene Expression RegulationGenetic Predisposition to DiseaseHomeostasisHost-Pathogen InteractionsHumansOrgan SpecificitySignal TransductionBiomarkersagingcancerinflammationmetabolic syndromesneurodegeneration
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