Evidence map›Paper›PMID 34458927›Full record

ArticleMolecular medicine reports2021

Involvement of autophagy in diosgenin‑induced megakaryocyte differentiation in human erythroleukemia cells.

Dima Diab, Aline Pinon, Catherine Ouk, Rouba Hage-Sleiman, Mona Diab-Assaf, Bertrand Liagre, David Yannick Leger

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular medicine reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Dima DiabPEIRENE Laboratory EA 7500, Faculty of Pharmacy, University of Limoges, 87025 Limoges, France.
Aline PinonPEIRENE Laboratory EA 7500, Faculty of Pharmacy, University of Limoges, 87025 Limoges, France.
Catherine OukBISCEm Flow Cytometry/Microscopy Unit, University of Limoges, 87025 Limoges, France.
Rouba Hage-SleimanDepartment of Biology, Faculty of Sciences, Lebanese University, Hadath El Jebbeh, Beyrouth 21219, Lebanon.
Mona Diab-AssafDoctoral School of Sciences and Technology, Lebanese University, Hadath El Jebbeh, Beyrouth 21219, Lebanon.
Bertrand Liagre *PEIRENE Laboratory EA 7500, Faculty of Pharmacy, University of Limoges, 87025 Limoges, France.
David Yannick Leger *PEIRENE Laboratory EA 7500, Faculty of Pharmacy, University of Limoges, 87025 Limoges, France.
Université de Limoges · FRLebanese University · LB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Natural agents have been used to restart the process of differentiation that is inhibited during leukemic transformation of hematopoietic stem or progenitor cells. Autophagy is a housekeeping pathway that maintains cell homeostasis against stress by recycling macromolecules and organelles and plays an important role in cell differentiation. In the present study, an experimental model was established to investigate the involvement of autophagy in the megakaryocyte differentiation of human erythroleukemia (HEL) cells induced by diosgenin [also known as (25

Indexed as

ApoptosisAutophagyCell DifferentiationCell LineDiosgeninHumansLeukemia, Erythroblastic, AcuteMegakaryocytesRNA, MessengerDiosgeninRNA, Messenger3‑methyladenineautophagydiosgeninhuman erythroleukemia cellsmegakaryocyte differentiation

Identifiers

PMID34458927
PMCPMC8436216
OpenAlexW3197204270

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.