Evidence map›Paper›PMID 34458873›Full record

ArticleSTAR protocols2021

A T-cell-based immunogenicity protocol for evaluating human antigen-specific responses.

Cansu Cimen Bozkus, Ana Belen Blazquez, Tomohiro Enokida, Nina Bhardwaj

Open access · goldAbstract read
In one paragraph

Article in STAR protocols, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
2.1field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 48 citations in OpenAlex.

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  5. Advanced Human Immune Cell-Organoid Co-Cultures for Functional Testing of Cancer Nanovaccines.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  6. Identification, design, andFrontiers in immunology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Cansu Cimen BozkusDepartment of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY 10127, USA.
Ana Belen BlazquezDepartment of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY 10127, USA.
Tomohiro EnokidaDepartment of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY 10127, USA.
Nina BhardwajDepartment of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY 10127, USA.
Icahn School of Medicine at Mount Sinai · USBristol-Myers Squibb (United States) · USChiba Cancer Center · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Determining the antigen specificities of the endogenous T-cell repertoire is important for screening naturally occurring or therapy-induced T-cell immunity and may help identify novel targets for T-cell-based therapies. Here, we describe a rapid, sensitive, and high-throughput protocol for expanding antigen-specific T cells from human peripheral blood mononuclear cells

Indexed as

Cell Culture TechniquesCryopreservationCytokinesFlow CytometryHumansImmunologic TechniquesLeukocytes, MononuclearT-Lymphocyte SubsetsCytokinesCell-based AssaysCell cultureFlow Cytometry/Mass CytometryHigh Throughput ScreeningImmunology

Identifiers

PMID34458873
PMCPMC8377590
OpenAlexW3194390213

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.