Evidence map›Paper›PMID 34458850›Full record

ArticleFunction (Oxford, England)2021

AKAP79 Orchestrates a Cyclic AMP Signalosome Adjacent to Orai1 Ca

Pulak Kar, Pradeep Barak, Anna Zerio, Yu-Ping Lin, Amy J Parekh, Val J Watts, Dermot M F Cooper, Manuela Zaccolo, Holger Kramer, Anant B Parekh

Open access · goldAbstract read
In one paragraph

Article in Function (Oxford, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
  3. Multifaceted control of T cell differentiation by STIM1.Trends in biochemical sciences · 2023
    Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Pulak KarDepartment of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, Oxford, OX1 3PT, UK.
Pradeep BarakDepartment of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, Oxford, OX1 3PT, UK.
Anna ZerioDepartment of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, Oxford, OX1 3PT, UK.
Yu-Ping LinDepartment of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, Oxford, OX1 3PT, UK.
Amy J ParekhStoke Mandeville Hospital, Mandeville Road, Aylesbury, HP21 8AL, UK.
Val J WattsDepartment of Medicinal Chemistry and Molecular Pharmacology, Purdue Institute of Drug Discovery, Purdue Institute of Neuroscience, Purdue University, West Lafayette, IN 47907, USA.
Dermot M F CooperDepartment of Pharmacology, Tennis Court Road, Cambridge CB2 1PD, UK.
Manuela ZaccoloDepartment of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, Oxford, OX1 3PT, UK.
Holger KramerProteomics and Metabolomics Centre, Medical Research Council, London Institute of Medical Sciences, London, W12 0NN, UK.
Anant B ParekhDepartment of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, Oxford, OX1 3PT, UK.
University of Oxford · GBLawn Tennis Association · GBMedical Research Council · GBPurdue University West Lafayette · USStoke Mandeville Hospital · GB

Funding

Understanding adaptive signaling of neuronal adenyly cyclases using siRNAR33MH101673 · NIMH · PURDUE UNIVERSITY · PI WATTS, VAL J · 2015 to 2016
$889k
Understanding adaptive signaling of neuronal adenyly cyclases using siRNAR21MH101673 · NIMH · PURDUE UNIVERSITY · PI WATTS, VAL J · 2014 to 2014
$261k
British Heart Foundation PG/15/5/31110British Heart Foundation RG/17/6/32944Medical Research Council L01047XNIMH NIH HHS R21 MH101673NIMH NIH HHS R33 MH101673Wellcome TrustWellcome Trust RG 31760
6 · The paper itself

Abstract

To ensure specificity of response, eukaryotic cells often restrict signalling molecules to sub-cellular regions. The Ca

Indexed as

Cyclic AMPCyclic AMP-Dependent Protein KinasesA Kinase Anchor ProteinsCell MembraneHEK293 CellsHumansORAI1 ProteinSignal TransductionAKAP5 protein, humanA Kinase Anchor ProteinsCyclic AMPCyclic AMP-Dependent Protein KinasesORAI1 ProteinORAI1 protein, humanadenylyl cyclase 8AKAP79calcium nanodomaincyclic AMPphosphodiesterasesignalosomeStore-operated calcium channels

Identifiers

PMID34458850
PMCPMC8394516
OpenAlexW3191074484

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.