ReviewRSC chemical biology2021
Enzymatic strategies for asymmetric synthesis.
Review in RSC chemical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Covalent Insertion of a Mn(Salen) Type Complex in Cross-Linked Protein Crystals: Design of an Enantioselective Artificial Epoxidase.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- Recent advances in AI-driven deep eutectic solvent design for biocatalysis: Co-design of extremozyme and reaction medium.Biodesign research · 2026Review
- Biocatalytic site- and stereoselective carbonyl desaturation for late-stage functionalization of cyclic ketones.Nature chemistry · 2026Article
- Stereoselective depolymerization of chiral polyesters.Nature communications · 2026Article
- A novel ene-reductase fromRSC advances · 2025Article
- Is a Malleable Active Site Loop the Key to High Substrate Promiscuity? Hybrid, Biocatalytic Route to Structurally Diverse Taxoid Side Chains with Remarkable Dual Stereocontrol.Angewandte Chemie (International ed. in English) · 2025Article
- Potassium binding by carbonyl clusters, halophilic adaptation and catalysis of Haloferax mediterranei D-2-hydroxyacid dehydrogenase.Communications biology · 2025Article
- Merging the computational design of chimeric type I polyketide synthases with enzymatic pathways for chemical biosynthesis.Nature communications · 2025Article
- Chemoenzymatic synthesis.Communications chemistry · 2025Article
- Unmasking the reverse catalytic activity of 'ene'-reductases for asymmetric carbonyl desaturation.Nature chemistry · 2025Article
- Substrate expansion of Geotrichum candidum alcohol dehydrogenase towards diaryl ketones by mutation.Applied microbiology and biotechnology · 2024Article
- Enzyme Catalysis for Sustainable Value Creation Using Renewable Biobased Resources.Molecules (Basel, Switzerland) · 2024Review
- Biocatalytic sulfation of aromatic and aliphatic alcohols catalyzed by arylsulfate sulfotransferases.Applied microbiology and biotechnology · 2024Article
- Asymmetric Synthesis of Chiral 2-Cyclohexenones with Quaternary Stereocenters via Ene-Reductase Catalyzed Desymmetrization of 2,5-Cyclohexadienones.ACS catalysis · 2024Article
- Towards Chemoenzymatic Syntheses of Both Enantiomers of Phosphoemeriamine.Molecules (Basel, Switzerland) · 2024Article
- Article
- Biocatalytic reduction of alkenes in micro-aqueous organic solvent catalysed by an immobilised ene reductase.Catalysis science & technology · 2023Article
- Easy and Versatile Technique for the Preparation of Stable and Active Lipase-Based CLEA-like Copolymers by Using Two Homofunctional Cross-Linking Agents: Application to the Preparation of Enantiopure Ibuprofen.International journal of molecular sciences · 2023Article
- An Up-to-Date Review on the Remediation of Dyes and Phenolic Compounds from Wastewaters Using Enzymes Immobilized on Emerging and Nanostructured Materials: Promises and Challenges.Nanomaterials (Basel, Switzerland) · 2023Review
- Biocatalytic Transamination of Aldolase-Derived 3-Hydroxy Ketones.Advanced synthesis & catalysis · 2023Article
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Abstract
Enzymes, at the turn of the 21st century, are gaining a momentum. Especially in the field of synthetic organic chemistry, a broad variety of biocatalysts are being applied in an increasing number of processes running at up to industrial scale. In addition to the advantages of employing enzymes under environmentally friendly reaction conditions, synthetic chemists are recognizing the value of enzymes connected to the exquisite selectivity of these natural (or engineered) catalysts. The use of hydrolases in enantioselective protocols paved the way to the application of enzymes in asymmetric synthesis, in particular in the context of biocatalytic (dynamic) kinetic resolutions. After two decades of impressive development, the field is now mature to propose a panel of catalytically diverse enzymes for (i) stereoselective reactions with prochiral compounds, such as double bond reduction and bond forming reactions, (ii) formal enantioselective replacement of one of two enantiotopic groups of prochiral substrates, as well as (iii) atroposelective reactions with noncentrally chiral compounds. In this review, the major enzymatic strategies broadly applicable in the asymmetric synthesis of optically pure chiral compounds are presented, with a focus on the reactions developed within the past decade.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.