Evidence map›Paper›PMID 34458798›Full record

ArticleRSC chemical biology2021

Revision in the first steps of the biosynthesis of the red antibiotic prodigiosin: use of a synthetic thioester to validate a new intermediate.

Maxime Couturier, Hiral D Bhalara, Rita E Monson, George P C Salmond, Finian J Leeper

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC chemical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Maxime CouturierYusuf Hamied Dept. of Chemistry, University of Cambridge Lensfield Road Cambridge CB2 1EW UK fjl1@cam.ac.uk.
Hiral D BhalaraYusuf Hamied Dept. of Chemistry, University of Cambridge Lensfield Road Cambridge CB2 1EW UK fjl1@cam.ac.uk.
Rita E MonsonDept. of Biochemistry, University of Cambridge Tennis Court Road Cambridge CB2 1QW UK.
George P C SalmondDept. of Biochemistry, University of Cambridge Tennis Court Road Cambridge CB2 1QW UK.
Finian J LeeperYusuf Hamied Dept. of Chemistry, University of Cambridge Lensfield Road Cambridge CB2 1EW UK fjl1@cam.ac.uk.ORCID https://orcid.org/0000-0003-3408-5199
University of Cambridge · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A biosynthetic pathway for the red-antibiotic, prodigiosin, was proposed over a decade ago but not all the suggested intermediates could be detected experimentally. Here we show that a thioester that was not originally included in the pathway is an intermediate. In addition, the enzyme PigE was originally described as a transaminase but we present evidence that it also catalyses the reduction of the thioester intermediate to its aldehyde substrate.

Identifiers

PMID34458798
PMCPMC8341465
OpenAlexW3120964724

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.