Evidence map›Paper›PMID 34458738›Full record

ArticleRSC medicinal chemistry2021

Synthesis and structure-activity relationships of 3,4,5-trisubstituted-1,2,4-triazoles: high affinity and selective somatostatin receptor-4 agonists for Alzheimer's disease treatment.

William L Neumann, Karin E Sandoval, Shirin Mobayen, Mahsa Minaeian, Stephen G Kukielski, Khush N Srabony, Rafael Frare, Olivia Slater, Susan A Farr, Michael L Niehoff and 4 more

Open access · greenAbstract read
In one paragraph

Article in RSC medicinal chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

William L NeumannDepartment of Pharmaceutical Sciences, School of Pharmacy, Southern Illinois University Edwardsville Edwardsville IL 62026 USA kwitt@siue.edu.
Karin E SandovalDepartment of Pharmaceutical Sciences, School of Pharmacy, Southern Illinois University Edwardsville Edwardsville IL 62026 USA kwitt@siue.edu.
Shirin MobayenDepartment of Pharmaceutical Sciences, School of Pharmacy, Southern Illinois University Edwardsville Edwardsville IL 62026 USA kwitt@siue.edu.
Mahsa MinaeianDepartment of Pharmaceutical Sciences, School of Pharmacy, Southern Illinois University Edwardsville Edwardsville IL 62026 USA kwitt@siue.edu.
Stephen G KukielskiDepartment of Pharmaceutical Sciences, School of Pharmacy, Southern Illinois University Edwardsville Edwardsville IL 62026 USA kwitt@siue.edu.
Khush N SrabonyDepartment of Pharmaceutical Sciences, School of Pharmacy, Southern Illinois University Edwardsville Edwardsville IL 62026 USA kwitt@siue.edu.ORCID https://orcid.org/0000-0003-4087-002X
Rafael FrareDepartment of Pharmaceutical Sciences, School of Pharmacy, Southern Illinois University Edwardsville Edwardsville IL 62026 USA kwitt@siue.edu.
Olivia SlaterDepartment of Pharmaceutical Sciences, School of Pharmacy, Southern Illinois University Edwardsville Edwardsville IL 62026 USA kwitt@siue.edu.
Susan A FarrResearch and Development Service, VA Medical Center, Division of Geriatric Medicine, Saint Louis University School of Medicine 1402 South Grand Boulevard, M238 St Louis MO 63104 USA.
Michael L NiehoffResearch and Development Service, VA Medical Center, Division of Geriatric Medicine, Saint Louis University School of Medicine 1402 South Grand Boulevard, M238 St Louis MO 63104 USA.
Audrey HospitalDepartment of Pharmaceutical Sciences, School of Pharmacy, Southern Illinois University Edwardsville Edwardsville IL 62026 USA kwitt@siue.edu.
Maria KontoyianniDepartment of Pharmaceutical Sciences, School of Pharmacy, Southern Illinois University Edwardsville Edwardsville IL 62026 USA kwitt@siue.edu.
A Michael CriderDepartment of Pharmaceutical Sciences, School of Pharmacy, Southern Illinois University Edwardsville Edwardsville IL 62026 USA kwitt@siue.edu.ORCID https://orcid.org/0000-0002-8638-7626
Ken A WittDepartment of Pharmaceutical Sciences, School of Pharmacy, Southern Illinois University Edwardsville Edwardsville IL 62026 USA kwitt@siue.edu.ORCID https://orcid.org/0000-0002-8575-8552
Southern Illinois University Edwardsville · USSaint Louis University · US

Funding

Lead optimization of somatostatin-based therapeutic for Alzheimer's DiseaseR01AG047858 · NIA · SOUTHERN ILLINOIS UNIV AT EDWARDSVILLE · PI WITT, KEN A · 2015 to 2019
$2.8M
NIA NIH HHS R01 AG047858
6 · The paper itself

Abstract

Somatostatin receptor-4 (SST

Identifiers

PMID34458738
PMCPMC8372316
OpenAlexW3165212912

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.