Evidence map›Paper›PMID 34458730›Full record

ArticleBrain communications2021

The contribution of beta-amyloid to dementia in Lewy body diseases: a 1-year follow-up study.

Roberta Biundo, Luca Weis, Eleonora Fiorenzato, Francesca Pistonesi, Annachiara Cagnin, Alessandra Bertoldo, Mariagiulia Anglani, Diego Cecchin, Angelo Antonini

Open access · goldAbstract read
In one paragraph

Article in Brain communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Heterogeneity of dementia with lewy bodies: Insights from clinical presentations, neuropathology, and biomarkers.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Design,Frontiers in pharmacology · 2023
    Article
  17. The journal of venomous animals and toxins including tropical diseases · 2023
    Article
  18. Article
  19. α-synuclein-assisted oligomerization of β-amyloid (1-42).Archives of biochemistry and biophysics · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Roberta BiundoDepartment of General Psychology, University of Padua, Padua, Italy.ORCID https://orcid.org/0000-0001-5846-755X
Luca WeisParkinson and Movement Disorders Unit, Department of Neuroscience, University of Padua, Padua, Italy.
Eleonora FiorenzatoDepartment of General Psychology, University of Padua, Padua, Italy.
Francesca PistonesiParkinson and Movement Disorders Unit, Department of Neuroscience, University of Padua, Padua, Italy.
Annachiara CagninDepartment of Neuroscience, University of Padua, Padua, Italy.
Alessandra BertoldoDepartment of Information Engineering, University of Padua, Padua, Italy.
Mariagiulia AnglaniNeuroradiology Unit, Padua University Hospital, Padua, Italy.
Diego CecchinPadova Neuroscience Center, University of Padua, Padua, Italy.
Angelo AntoniniParkinson and Movement Disorders Unit, Department of Neuroscience, University of Padua, Padua, Italy.
University of Padua · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dementia in Lewy Body Diseases (Parkinson's disease and dementia with Lewy Bodies) affects progression of disabilities, quality of life and well-being. Understanding its pathogenetic mechanisms is critical to properly implement disease-modifying strategies. It has been hypothesized that synuclein- and amyloid-pathology act synergistically aggravating cognitive decline in elderly patients but their precise contribution to dementia is debated. In this study, we aimed at exploring if presence of amyloid deposits influences clinical, cognitive and neuroanatomical correlates of mental decline in a cohort of 40 Parkinson's disease patients with normal cognition (

Indexed as

amyloidcognitive dysfunctiondementia with Lewy bodiesParkinson’s diseasePET/MRI

Identifiers

PMID34458730
PMCPMC8390473
OpenAlexW3196175436

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.