ArticleiScience2021
Region-specific effects of ultrasound on individual neurons in the awake mammalian brain.
Article in iScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Deep brain stimulation reduces subthalamic nucleus pathological dynamics and rescues gait deficits associated with dopamine loss.bioRxiv : the preprint server for biology · 2026Article
- A panoramic review of transcranial focused ultrasound neuromodulation: from basic research to clinical applications.Journal of neuroengineering and rehabilitation · 2025Review
- Review
- Kilohertz electrical stimulation evokes robust cellular responses like conventional frequencies but distinct population dynamics.Communications biology · 2025Article
- Force versus Response: Methods for Activating and Characterizing Mechanosensitive Ion Channels and GPCRs.Advanced healthcare materials · 2024Review
- Beta-frequency sensory stimulation enhances gait rhythmicity through strengthened coupling between striatal networks and stepping movement.Nature communications · 2024Article
- Ultrasound pulse repetition frequency preferentially activates different neuron populations independent of cell type.Journal of neural engineering · 2024Article
- Repeated diagnostic ultrasound exposure modifies the structural properties of CA1 dendrites and alters the hippocampal transcriptome.Scientific reports · 2024Article
- Implantable acousto-optic window for monitoring ultrasound-mediated neuromodulationNeurophotonics · 2022Article
- Toward a transcriptomic framework for ultrasound neuromodulation: A perspective on gene expression and regional brain sensitivity.Imaging neuroscience (Cambridge, Mass.)Article
- Transcranial ultrasound stimulation modulates neuronal membrane potentials across broad timescales in the awake mammalian brain.Brain stimulationArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Ultrasound modulates brain activity. However, it remains unclear how ultrasound affects individual neurons in the brain, where neural circuit architecture is intact and different brain regions exhibit distinct tissue properties. Using a high-resolution calcium imaging technique, we characterized the effect of ultrasound stimulation on thousands of individual neurons in the hippocampus and the motor cortex of awake mice. We found that brief 100-ms-long ultrasound pulses increase intracellular calcium in a large fraction of individual neurons in both brain regions. Ultrasound-evoked calcium response in hippocampal neurons exhibits a rapid onset with a latency shorter than 50 ms. The evoked response in the hippocampus is shorter in duration and smaller in magnitude than that in the motor cortex. These results demonstrate that noninvasive ultrasound stimulation transiently increases intracellular calcium in individual neurons in awake mice, and the evoked response profiles are brain region specific.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.