ArticleInternational journal of reproductive biomedicine2021
Complementary effects of coenzyme Q10 and
Article in International journal of reproductive biomedicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 10 citations in OpenAlex.
- Animal models for improving reproductive efficiency using medicinal plants: A review.Open veterinary journal · 2026Review
- Effects of varying concentrations of Ubiquinol (coenzyme Q10) on physiological parameters in male donkeys (Frontiers in veterinary science · 2026Article
- Understanding the intricate impacts and mechanism of actions of adaptogens on reproductive function.Cell biochemistry and biophysics · 2025Review
- Treatment of D-galactose-induced rat polycystic ovarian condition usingJournal of advanced veterinary and animal research · 2024Article
- Research Update on the Therapeutic Potential of Garden Cress (Current drug research reviews · 2024Review
- Garden Cress Seed Oil Abrogates Testicular Oxidative Injury and NF-kB-Mediated Inflammation in Diabetic Mice.International journal of molecular sciences · 2023Article
- Evidence for Health-Promoting Properties ofTurkish journal of pharmaceutical sciences · 2022Article
- Reproductive performance and milk yield of rabbits fed diets supplemented with garden cress (Lepidium sativum) seed.Scientific reports · 2022Article
- The Modulation of Ubiquinone, a Lipid Antioxidant, on Neuronal Voltage-Gated Sodium Current.Nutrients · 2022Article
- Exceptional Properties ofMolecules (Basel, Switzerland) · 2022Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCoenzyme Q10 (CoQ10) and
objectiveTo evaluate the combined effects of LS and CoQ10 on reproductive function in adult male NMRI mice. MATERIALS AND
methodsEighty three-months-old male mice (35-40 gr) were divided into four groups (n = 10/each): control (treated with water), CoQ10-treated (200, 300, and 400 mg/kg/body weight), LS-treated (200, 400, 600 mg/kg/body weight), and co-treated (LS [600 mg/kg/body weight] + CoQ10 [200 mg/kg/body weight]) groups. Serum testosterone, luteinizing hormone, follicle-stimulating hormone, and gonadotropin realizing hormone (GnRH) levels were measured using ELISA method. The sperm quality was assessed using Sperm Class AnalyzerⓇ (SCA) CASA system and GnRH mRNA expression levels were evaluated by real-time polymerase chain reaction.
resultsThe number of sniffing and following behavior was significantly higher in LS-treated (400 and 600 mg/ml/body weight) groups than the control group (p = 0.0007 and p = 0.0010, respectively). The number of mounting and coupling behaviors was significantly higher in the CoQ10 (300 and 400 mg/ml/body weight)-treated animals than the control group (p = 0.0170 and p = 0.0006, respectively). Co-treatment of CoQ10 (200 mg/ml/body weight) and LS (600 mg/ml/body weight) significantly increased all aspects of sexual behaviors as well as the levels of serum testosterone (p = 0.0011), luteinizing hormone (p = 0.0062), and follicle-stimulating hormone (p = 0.0001); sperm viability (p = 0.0300) and motility (p = 0.0010); and GnRH mRNA levels (p = 0.0016) compared to the control group.
conclusionThe coadministration of CoQ10 and LS significantly improves the activity of the hypothalamic-pituitary-gonadal axis and enhances the reproductive parameters in adult male mice.
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