Evidence map›Paper›PMID 34458652›Full record

ArticleCurrent opinion in biomedical engineering2021

Biomaterials for Orthopaedic Diagnostics and Theranostics.

Marian A Ackun-Farmmer, Clyde T Overby, Brittany E Haws, Regine Choe, Danielle S W Benoit

Abstract read
In one paragraph

Article in Current opinion in biomedical engineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Review
  3. Current Uses for Medical Imaging With Orthopaedic Implant Technology.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026
    Review
  4. A Patent Analysis on Nano Drug Delivery Systems.Recent patents on nanotechnology · 2025
    Review
  5. Review
  6. Article
  7. Review
  8. Biomaterials and Regenerative Medicine in Pain Management.Current pain and headache reports · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Marian A Ackun-FarmmerDepartment of Biomedical Engineering, University of Rochester, Rochester, NY, USA.
Clyde T OverbyDepartment of Biomedical Engineering, University of Rochester, Rochester, NY, USA.
Brittany E HawsDepartment of Orthopaedics, University of Rochester, Rochester, NY, USA.
Regine ChoeDepartment of Biomedical Engineering, University of Rochester, Rochester, NY, USA.
Danielle S W BenoitDepartment of Biomedical Engineering, University of Rochester, Rochester, NY, USA.

Funding

The University of Rochester's Clinical and Translational Science InstituteUL1TR002001 · NCATS · UNIVERSITY OF ROCHESTER · PI WILSON, KAREN M., ZAND, MARTIN S · 2016 to 2024
$34.6M
Rochester Resource-Based Center for Bone, Muscle and Orthopaedic Research (ROCSTARR) (Overall Application)P30AR069655 · NIAMS · UNIVERSITY OF ROCHESTER · PI Edward M. Schwarz · 2016 to 2026
$7.8M
Tissue Engineering Strategies to Revitalize Bone AllograftsR01AR064200 · NIAMS · UNIVERSITY OF ROCHESTER · PI Danielle S. Benoit · 2013 to 2026
$4.0M
Engineering scarless repair of flexor tendon injuriesR01AR056696 · NIAMS · UNIVERSITY OF ROCHESTER · PI AWAD, HANI A, BENOIT, DANIELLE S. · 2009 to 2019
$3.6M
Longitudinal monitoring of bone fracture healing using diffuse optical and correlation tomographyR01AR071363 · NIAMS · UNIVERSITY OF ROCHESTER · PI REGINE CHOE · 2017 to 2026
$2.2M
Development of Anti-Fouling Peptide-Nanoparticle Conjugates for the Delivery of siRNA to FracturesF31AR076874 · NIAMS · UNIVERSITY OF ROCHESTER · PI OVERBY, CLYDE THOMAS · 2020 to 2022
$138k
Nanoparticle mediated microenvironmental targeting of CCL3 signaling for the treatment of acute myelogenous leukemiaF31CA228391 · NCI · UNIVERSITY OF ROCHESTER · PI ACKUN-FARMMER, MARIAN ADRIANA · 2018 to 2020
$94k
NCATS NIH HHS UL1 TR002001NCI NIH HHS F31 CA228391NIAMS NIH HHS F31 AR076874NIAMS NIH HHS P30 AR069655NIAMS NIH HHS R01 AR056696NIAMS NIH HHS R01 AR064200NIAMS NIH HHS R01 AR071363
6 · The paper itself

Abstract

Despite widespread use of conventional diagnostic methods in orthopaedic applications, limitations still exist in detection and diagnosing many pathologies especially at early stages when intervention is most critical. The use of biomaterials to develop diagnostics and theranostics, including nanoparticles and scaffolds for systemic or local applications, has significant promise to address these shortcomings and enable successful clinical translation. These developments in both modular and holistic design of diagnostic and theranostic biomaterials may improve patient treatments for myriad orthopaedic applications ranging from cancer to fractures to infection.

Identifiers

PMID34458652
PMCPMC8386480

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.