Evidence map›Paper›PMID 34458647›Full record

ArticleNeurobiology of pain (Cambridge, Mass.)

Single-chain Fragment variable antibody targeting cholecystokinin-B receptor for pain reduction.

K N Westlund, M A Montera, A E Goins, S R A Alles, M Afaghpour-Becklund, R Bartel, R Durvasula, A Kunamneni

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of pain (Cambridge, Mass.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. Doxazosin Alleviates Chronic Orofacial Pain.International journal of molecular sciences · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. CCK2 receptors in chronic pain.Neurobiology of pain (Cambridge, Mass.)
    Review
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

K N WestlundDepartment of Anesthesiology & Critical Care Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87106-0001, USA.
M A MonteraDepartment of Anesthesiology & Critical Care Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87106-0001, USA.
A E GoinsDepartment of Anesthesiology & Critical Care Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87106-0001, USA.
S R A AllesDepartment of Anesthesiology & Critical Care Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87106-0001, USA.
M Afaghpour-BecklundDepartment of Anesthesiology & Critical Care Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87106-0001, USA.
R BartelDepartment of Anesthesiology & Critical Care Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87106-0001, USA.
R DurvasulaDivision of Infectious Diseases, Department of Internal Medicine, Mayo Clinic, Jacksonville, FL, USA.
A KunamneniDivision of Infectious Diseases, Department of Internal Medicine, Mayo Clinic, Jacksonville, FL, USA.
University of New Mexico · USLoyola University Medical Center · US

Funding

NEUROGENIC AMPLIFICATION OF PANCREATITIS PAINR01NS039041 · NINDS · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI WESTLUND-HIGH, KARIN N. · 2000 to 2014
$4.8M
scFv Antibody Therapy for Chronic Trigeminal Neuropathic PainR21DE028096 · NIDCR · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI KUNAMNENI, ADINARAYANA, WESTLUND-HIGH, KARIN N. · 2019 to 2020
$430k
BLRD VA I01 BX002695NIDCR NIH HHS R21 DE028096NINDS NIH HHS R01 NS039041
6 · The paper itself

Abstract

The cholecystokinin B receptor and its neuropeptide ligand are upregulated in chronic neuropathic pain models. Single-chain Fragment variable antibodies were generated as preferred non-opioid targeting therapy blocking the cholecystokinin B receptor to inhibit chronic neuropathic pain models

Indexed as

ANOVA, analysis of varianceAnxietyARM, antibody ribosome mRNABBB, blood–brain barrierCCK-8, cholecystokinin octapeptideCCK-BR, cholecystokinin B receptorChronic painCPP, conditioned place preferenceDepressionDRG, dorsal root gangliaEukaryotic ribosome displayFRICT-ION, foramen rotundum inflammatory compression trigeminal infraorbital nerve modelGPCR, G-protein-coupled receptorIACUC, Institutional Animal Care and Use CommitteeION, infraorbital nervems, millisecondsMΩ, megaOhmspA, picoAmpsPBS, phosphate buffered salinescFvscFv, single-chain Fragment variable antibodySEM, standard error of the meanTG, trigeminal ganglia

Identifiers

PMID34458647
PMCPMC8378781
OpenAlexW3184580316

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.