ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2021
Association of walking energetics with amyloid beta status: Findings from the Baltimore Longitudinal Study of Aging.
Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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The trial behind it
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.
- Early detection of diseases causing dementia using digital navigation and gait measures: A systematic review of evidence.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Pooled it
- The effect of exercise on walking economy in patients with chronic neurological conditions: A systematic review and meta-analysis.Frontiers in neurology · 2022Pooled it
- Rising energetic cost of walking predicts cognitive impairment.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Association of mitochondrial oxidative capacity with physical fitness in ageing: the Baltimore longitudinal study of ageing.Age and ageing · 2026Article
- Adolescent IQ and performance-based measures of physical function in old age: a 54-year longitudinal study.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
- Pulmonary V̇OExperimental gerontology · 2025Article
- Distinctive Gait Variations and Neuroimaging Correlates in Alzheimer's Disease and Cerebral Small Vessel Disease.Journal of cachexia, sarcopenia and muscle · 2024Article
- Balance, Strength, and Risk of Dementia: Findings From the Health and Retirement Study and the English Longitudinal Study of Ageing.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Differences in Daily Physical Activity by Alzheimer's Risk Markers Among Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Energetic Cost of Walking and Brain Atrophy in Mid-to-Late Life.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Longitudinal associations between energy utilization and brain volumes in cognitively normal middle aged and older adults.Scientific reports · 2022Article
- Association of walking energetics with amyloid beta status: Findings from the Baltimore Longitudinal Study of Aging.Alzheimer's & dementia (Amsterdam, Netherlands) · 2021Article
- Walking energetics and white matter hyperintensities in mid-to-late adulthood.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
introductionHigher energetic costs for mobility predict gait speed decline. Slow gait is linked to cognitive decline and Alzheimer's disease (AD). Whether the energetic cost of walking is linked to AD pathology is unknown. We investigated the cross-sectional association between the energetic cost of walking, gait speed, and amyloid beta (Aβ) status (+/-) in older adults.
methodsOne hundred forty-nine cognitively normal adults (56% women, mean age 77.5 ± 8.4 years) completed customary-paced walking assessments with indirect calorimetry and
resultsEach 0.01 mL/kg/m greater energy cost was associated with 18% higher odds of being Aβ+ (odds ratio [OR] = 1.18; 95% confidence interval [CI]: 1.04 to 1.34; DISCUSSION: High energetic cost of walking is linked to AD pathology and may be a potential target for therapeutic intervention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.