ArticleNeurobiology of stress2021
Gene expression correlates of advanced epigenetic age and psychopathology in postmortem cortical tissue.
Article in Neurobiology of stress, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Posttraumatic Stress Disorder Severity-related Accelerated Aging, Hippocampal Volume, and CLDN5 DNA Methylation.Biopsychosocial science and medicine · 2026Article
- Trauma exposure, PTSD, and methylation of the blood brain barrier claudin-5 gene.Psychoneuroendocrinology · 2026Article
- Blood transcriptomic associations of epigenetic age in adolescents.Epigenetics · 2025Article
- Trauma Exposure, PTSD, and Methylation of the Blood Brain Barrier Claudin-5 Gene.medRxiv : the preprint server for health sciences · 2025Article
- Association between triglyceride-glucose index and phenotypic age acceleration: a cross-sectional study based on NHANES database.Frontiers in physiology · 2025Article
- Systems biology dissection of PTSD and MDD across brain regions, cell types, and blood.Science (New York, N.Y.) · 2024Article
- Longitudinal study of traumatic-stress related cellular and cognitive aging.Brain, behavior, and immunity · 2024Article
- Biomarkers of Neurodegeneration in Post-Traumatic Stress Disorder: An Integrative Review.Biomedicines · 2023Review
- Stressful life events and accelerated biological aging over time in youths.Psychoneuroendocrinology · 2023Article
- Glial Cell Metabolic Profile Upon Iron Deficiency: Oligodendroglial and Astroglial Casualties of Bioenergetic Adjustments.Molecular neurobiology · 2023Article
- Genetics and epigenetics of stress: New avenues for an old concept.Neurobiology of stress · 2023Article
- PTSD, major depression, and advanced transcriptomic age in brain tissue.Depression and anxiety · 2022Article
- Sex-specific transcriptomic and epitranscriptomic signatures of PTSD-like fear acquisition.iScience · 2022Article
- Central and Peripheral Immune Dysregulation in Posttraumatic Stress Disorder: Convergent Multi-Omics Evidence.Biomedicines · 2022Review
- The role of extracellular vesicle miRNAs and tRNAs in synovial fibroblast senescence.Frontiers in molecular biosciences · 2022Article
- Cross-Species Convergence of Brain Transcriptomic and Epigenomic Findings in Posttraumatic Stress Disorder: A Systematic Review.Complex psychiatryReview
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Psychiatric stress has been associated with accelerated epigenetic aging (i.e., when estimates of cellular age based on DNA methylation exceed chronological age) in both blood and brain tissue. Little is known about the downstream biological effects of accelerated epigenetic age on gene expression. In this study we examined associations between DNA methylation-derived estimates of cellular age that range from decelerated to accelerated relative to chronological age ("DNAm age residuals") and transcriptome-wide gene expression. This was examined using tissue from three post-mortem cortical regions (ventromedial and dorsolateral prefrontal cortex and motor cortex,
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