ArticleJournal of diabetes research2021
Relationship between Hyponatremia and Peripheral Neuropathy in Patients with Diabetes.
Article in Journal of diabetes research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- Adolescent Girls With Type 1 Diabetes Develop Changes in Bone Prior to Evidence of Clinical Neuropathy.The Journal of clinical endocrinology and metabolism · 2025Article
- Rodent Models of Diabetic Neuropathy, Role of Calcium Homeostasis in Pain and KB-R7943 as a Potential Therapeutic.International journal of molecular sciences · 2025Review
- Relationship Between Serum Osmolality and Diabetic Foot Ulcers in a US Population With Diabetes: Results From NHANES 1999-2004.International journal of endocrinology · 2025Article
- Therapeutic potential of orally applied KB-R7943 in streptozotocin-induced neuropathy in rats.Heliyon · 2024Article
- Hyponatremia-induced worsening of trigeminal neuralgia- When the sodium plays the game.Journal of family medicine and primary care · 2024Article
- The mediating role of HbA1c in the association between elevated low-density lipoprotein cholesterol levels and diabetic peripheral neuropathy in patients with type 2 diabetes mellitus.Lipids in health and disease · 2023Article
- A Nomogram for Predicting the Possibility of Peripheral Neuropathy in Patients with Type 2 Diabetes Mellitus.Brain sciences · 2022Article
- The association between normal serum sodium levels and bone turnover in patients with type 2 diabetes.Frontiers in endocrinology · 2022Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesHyponatremia is a common complication of diabetes. However, the relationship between serum sodium level and diabetic peripheral neuropathy (DPN) is unknown. This study was aimed at investigating the relationship between low serum sodium level and DPN in Chinese patients with type 2 diabetes mellitus.
methodsA retrospective study was performed on 1928 patients with type 2 diabetes between 2010 and 2018. The multivariate test was used to analyze the relationship between the serum sodium level and the nerve conduction function. A restricted cubic spline was used to flexibly model and visualize the relationship between the serum sodium level and DPN, followed by logistic regression with adjustment.
resultsAs the serum sodium level increased, the prevalence of DPN had a reverse J-curve distribution with the serum sodium levels (69.6%, 53.7%, 49.6%, 43.9%, and 49.7%;
conclusionsLow serum sodium levels were independently associated with DPN, even within the normal range of the serum sodium. We should pay more attention to avoid the low serum sodium level in patients with type 2 diabetes mellitus.
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