ArticleFrontiers in veterinary science2021
Plasma Metabolomics Reveals Pathogenesis of Retained Placenta in Dairy Cows.
Article in Frontiers in veterinary science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Bovine alkaline phosphatase in health and disease: A bibliometric and narrative review.Veterinary and animal science · 2026Review
- Prepartum Blood Biochemistry and Periparturient Disease Risk in Dairy Cows: A Retrospective Two-Farm Study.Animals : an open access journal from MDPI · 2026Article
- Article
- An exploratory study on the placental efficiency, histomorphometric characteristics, hormonal shifts, and oxidative stress in dromedary camels with dystocia.Frontiers in veterinary science · 2026Article
- Applications of metabolomics in cow health assessment.Metabolomics : Official journal of the Metabolomic Society · 2025Review
- Assessment of the physical and chemical properties of vaginal discharge for the diagnosis of endometritis in dairy cattle.Veterinary world · 2025Article
- The Relationship of ThVeterinary medicine and science · 2025Article
- Efficacy of an herbal formula Guixiong Yimu San in preventing retained placenta and improving reproductive performance in cows.Scientific reports · 2024Article
- Differences of serum glucose and lipid metabolism and immune parameters and blood metabolomics regarding the transition cows in the antepartum and postpartum period.Frontiers in veterinary science · 2024Article
- Profiling the alterations of serum proteome in dairy cows with retained placenta using high-throughput tandem mass tags quantitative approach.The veterinary quarterly · 2023Article
- Acute and 28-Day Repeated-Dose Oral Toxicity of the Herbal Formula Guixiong Yimu San in Mice and Sprague-Dawley Rats.Veterinary sciences · 2023Article
- Effect of short time precise dietary energy-protein in reproductive parameters of local crossbred dairy goats.Journal of advanced veterinary and animal research · 2023Article
- Gene expression profile of placentomes and clinical parameters in the cows with retained placenta.BMC genomics · 2022Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The complex etiology and pathogenesis of retained placenta (RP) bring huge challenges for researchers and clinical veterinarians in investigating the pathogenesis and treatment schedule. This study aims to investigate the pathogenesis of RP in dairy cows by plasma metabolomics. As subjects, 10 dairy cows with RP and 10 healthy dairy cows were enrolled according to strict enrollment criteria. Imbalanced antioxidant capacity, reduced Th1/Th2 cytokine ratio, and deregulation of total bilirubin (T-bil), alkaline phosphatase (ALP), and reproductive hormones were shown in dairy cows with RP by detecting biochemical indicators, oxidation and antioxidant markers, and cytokines in serum. Plasma metabolites were detected and analyzed by a liquid chromatography-mass spectrometry (LC-MS) system coupled with multivariate statistical analysis software. A total of 23 potential biomarkers were uncovered in the plasma of dairy cows with RP. The metabolic pathways involved in these potential biomarkers are interconnected, and the conversion, utilization, and excretion of nitrogen were disturbed in dairy cows with RP. Moreover, these potential biomarkers are involved in the regulation of antioxidant capacity, inflammation, and autocrine or paracrine hormone. All of these findings suggest that an imbalance of these potential biomarkers might be responsible for the imbalanced antioxidant capacity, reduced Th1/Th2 cytokine ratio, and deregulation of reproductive hormones in dairy cows with RP. The regulation of metabolic pathways involved in these potential biomarkers represents a promising therapeutic strategy for RP.
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