Evidence map›Paper›PMID 34458332›Full record

ArticleFrontiers in cardiovascular medicine2021

Integration of Functional Imaging, Cytometry, and Unbiased Proteomics Reveals New Features of Endothelial-to-Mesenchymal Transition in Ischemic Mitral Valve Regurgitation in Human Patients.

Adrien Lupieri, Yasufumi Nagata, Livia S A Passos, Dakota Beker-Greene, Katherine A Kirkwood, Jill Wylie-Sears, Zahra Alvandi, Hideyuki Higashi, Judy W Hung, Sasha A Singh and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cardiovascular medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Recent advances in omics-based research of mitral valve disease.Frontiers in cardiovascular medicine · 2026
    Review
  3. Review
  4. Immunotherapy in the Context of Aortic Valve Diseases.Cardiovascular drugs and therapy · 2024
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Adrien LupieriDivision of Cardiovascular Medicine, Center for Excellence in Vascular Biology and Harvard Medical School, Brigham and Women's Hospital, Boston, MA, United States.
Yasufumi NagataCardiac Ultrasound Laboratory and Harvard Medical School, Massachusetts General Hospital, Boston, MA, United States.
Livia S A PassosDivision of Cardiovascular Medicine, Center for Excellence in Vascular Biology and Harvard Medical School, Brigham and Women's Hospital, Boston, MA, United States.
Dakota Beker-GreeneDivision of Cardiovascular Medicine, Center for Excellence in Vascular Biology and Harvard Medical School, Brigham and Women's Hospital, Boston, MA, United States.
Katherine A KirkwoodDepartment of Population Health Science and Policy, Icahn School of Medicine, International Center for Health Outcomes and Innovation Research, New York, NY, United States.
Jill Wylie-SearsVascular Biology Program and Department of Surgery, Boston Children's Hospital and Department of Surgery and Harvard Medical School, Boston, MA, United States.
Zahra AlvandiVascular Biology Program and Department of Surgery, Boston Children's Hospital and Department of Surgery and Harvard Medical School, Boston, MA, United States.
Hideyuki HigashiDivision of Cardiovascular Medicine, Center for Interdisciplinary Cardiovascular Sciences and Harvard Medical School, Brigham and Women's Hospital, Boston, MA, United States.
Judy W HungEchocardiography Laboratory, Division of Cardiology and Harvard Medical School, Massachusetts General Hospital, Boston, MA, United States.
Sasha A SinghDivision of Cardiovascular Medicine, Center for Interdisciplinary Cardiovascular Sciences and Harvard Medical School, Brigham and Women's Hospital, Boston, MA, United States.
Joyce BischoffVascular Biology Program and Department of Surgery, Boston Children's Hospital and Department of Surgery and Harvard Medical School, Boston, MA, United States.
Robert A LevineCardiac Ultrasound Laboratory and Harvard Medical School, Massachusetts General Hospital, Boston, MA, United States.
Elena AikawaDivision of Cardiovascular Medicine, Center for Excellence in Vascular Biology and Harvard Medical School, Brigham and Women's Hospital, Boston, MA, United States.

Funding

PROGRAM IN BLOOD COAGULATION AND VASCULAR BIOLOGYT32HL007917 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Robert C Flaumenhaft · 1999 to 2026
$11.1M
NHLBI NIH HHS T32 HL007917
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

echocardiographyendothelial-to-mesenchymal transitionhisto-cytometryischemic mitral regurgitationmitral valveproteomics

Identifiers

PMID34458332
PMCPMC8387660

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.