Evidence map›Paper›PMID 34458259›Full record

ArticleFrontiers in cell and developmental biology2021

Differential and Prognostic Significance of HOXB7 in Gliomas.

Xingang Zhou, Tingyu Liang, Jinhai Deng, Kenrick Ng, Man Li, Chunxin Lv, Jiamin Chen, Kun Yang, Zhiyuan Ma, Wenping Ma and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 2 countries.

Xingang ZhouDepartment of Pathology, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
Tingyu LiangDepartment of Neurosurgery, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
Jinhai DengKey Laboratory of Medical Immunology, School of Basic Medical Sciences, Peking University Center for Human Disease Genomics, Peking University Health Science Center, Beijing, China.
Kenrick NgDepartment of Medical Oncology, University College London Cancer Institute, London, United Kingdom.
Man LiDepartment of Pathology, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
Chunxin LvGeriatric Department, Minhang Hospital, Fudan University, Shanghai, China.
Jiamin ChenDepartment of Pathology, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
Kun YangDepartment of Pathology, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
Zhiyuan MaDepartment of Pathology, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
Wenping MaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Peng WangDepartment of Pathology, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
Capital Medical University · CNBeijing Ditan Hospital · CNBeijing Tian Tan Hospital · CNKing's College London · GBMinhang District Central Hospital · CNUniversity College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diffuse glioma is the most common primary tumor of the central nervous system. The prognosis of the individual tumor is heavily dependent on its grade and subtype. Homeobox B7 (HOXB7), a member of the homeobox family, is abnormally overexpressed in a variety of tumors. However, its function in glioma is unclear. In this study, HOXB7 mRNA and protein expression levels were analyzed in 401 gliomas from the CGGA RNA-seq database (325 cases) and our hospital (76 cases). HOXB7 expression, at both mRNA and protein levels, were upregulated in glioblastoma (GBM) and isocitrate dehydrogenase 1 (

Indexed as

astrocytomaHOXB7immunohistochemistryoligodendrogliomaprognosis

Identifiers

PMID34458259
PMCPMC8385304
OpenAlexW3191914737

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.