Evidence map›Paper›PMID 34458252›Full record

ReviewFrontiers in cell and developmental biology2021

Microfluidics-Based Single-Cell Research for Intercellular Interaction.

Long Pang, Jing Ding, Xi-Xian Liu, Zhixuan Kou, Lulu Guo, Xi Xu, Shih-Kang Fan

Abstract readReview
In one paragraph

Review in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Cell-cell communication: new insights and clinical implications.Signal transduction and targeted therapy · 2024
    Review
  8. Article
  9. Article
  10. Droplets microfluidics platform-A tool for single cell research.Frontiers in bioengineering and biotechnology · 2023
    Review
  11. Review
  12. On the quest of reliable 3D dynamicFrontiers in bioengineering and biotechnology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Long PangSchool of Basic Medical Science, The Shaanxi Key Laboratory of Brain Disorders, Xi'an Medical University, Xi'an, China.
Jing DingDepartment of Mechanical and Nuclear Engineering, Kansas State University, Manhattan, KS, United States.
Xi-Xian LiuKey Laboratory of Thermo-Fluid Science and Engineering of MOE, School of Energy and Power Engineering, Xi'an Jiaotong University, Xi'an, China.
Zhixuan KouSchool of Basic Medical Science, The Shaanxi Key Laboratory of Brain Disorders, Xi'an Medical University, Xi'an, China.
Lulu GuoSchool of Basic Medical Science, The Shaanxi Key Laboratory of Brain Disorders, Xi'an Medical University, Xi'an, China.
Xi XuSchool of Basic Medical Science, The Shaanxi Key Laboratory of Brain Disorders, Xi'an Medical University, Xi'an, China.
Shih-Kang FanDepartment of Mechanical and Nuclear Engineering, Kansas State University, Manhattan, KS, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intercellular interaction between cell-cell and cell-ECM is critical to numerous biology and medical studies, such as stem cell differentiation, immunotherapy and tissue engineering. Traditional methods employed for delving into intercellular interaction are limited by expensive equipment and sophisticated procedures. Microfluidics technique is considered as one of the powerful measures capable of precisely capturing and manipulating cells and achieving low reagent consumption and high throughput with decidedly integrated functional components. Over the past few years, microfluidics-based systems for intercellular interaction study at a single-cell level have become frequently adopted. This review focuses on microfluidic single-cell studies for intercellular interaction in a 2D or 3D environment with a variety of cell manipulating techniques and applications. The challenges to be overcome are highlighted.

Indexed as

cell-cell communicationcell culturemicrofluidic technologysingle-cell analysissingle-cell manipulation

Identifiers

PMID34458252
PMCPMC8397490

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.